IGF2 Actions on Trophoblast in Human Placenta Are Regulated by the Insulin-Like Growth Factor 2 Receptor, Which Can Function as Both a Signaling and Clearance Receptor

Insulin-like growth factor 2 (IGF2) enhances proliferation and survival of human first-trimester cytotrophoblasts (CTB) by signaling through the insulin-like growth factor 1 receptor (IGF1R). However, the role of the IGF2 receptor (IGF2R) in regulating trophoblast kinetics is unclear: It could act a...

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Veröffentlicht in:	Biology of reproduction 2011-03, Vol.84 (3), p.440-446
Hauptverfasser:	Harris, Lynda K, Crocker, Ian P, Baker, Philip N, Aplin, John D, Westwood, Melissa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Biological and medical sciences Cell Survival - drug effects Cell Survival - genetics Cells, Cultured Female Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Humans Insulin-Like Growth Factor II - metabolism Insulin-Like Growth Factor II - pharmacokinetics Insulin-Like Growth Factor II - pharmacology Insulin-Like Growth Factor II - physiology Metabolic Clearance Rate Mitosis - drug effects Mitosis - genetics Models, Biological Placenta - drug effects Placenta - metabolism Placenta - physiology Pregnancy Protein Processing, Post-Translational - physiology Receptor, IGF Type 2 - antagonists & inhibitors Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism Receptor, IGF Type 2 - physiology RNA, Small Interfering - pharmacology Transfection Trophoblasts - cytology Trophoblasts - drug effects Trophoblasts - metabolism Trophoblasts - physiology Vertebrates: reproduction
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