Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

In mammals, left-right (L-R) asymmetry is established by posteriorly oriented cilia driving a leftwards laminar flow in the embryonic node, thereby activating asymmetric gene expression. The two-cilia hypothesis argues that immotile cilia detect and respond to this flow through a Pkd2-mediated mecha...

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Veröffentlicht in:	Development (Cambridge) 2011-03, Vol.138 (6), p.1131-1142
Hauptverfasser:	Field, Sarah, Riley, Kerry-Lyn, Grimes, Daniel T, Hilton, Helen, Simon, Michelle, Powles-Glover, Nicola, Siggers, Pam, Bogani, Debora, Greenfield, Andy, Norris, Dominic P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Body Patterning - genetics Body Patterning - physiology Cells, Cultured Cilia - genetics Cilia - metabolism Cilia - physiology Gene Expression Regulation, Developmental Humans Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - physiology Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Models, Biological Models, Molecular Molecular Sequence Data Polymorphism, Single Nucleotide - genetics Polymorphism, Single Nucleotide - physiology Protein Binding - genetics Protein Binding - physiology Sequence Homology, Amino Acid TRPP Cation Channels - genetics TRPP Cation Channels - metabolism TRPP Cation Channels - physiology
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