Adiposity, leptin and stress reactivity in humans
Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses...
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| Veröffentlicht in: | Biological psychology 2011-02, Vol.86 (2), p.114-120 |
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| creator | Brydon, Lena |
| description | Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptor antagonist (IL-1Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. Our findings suggest that the cytokines leptin and IL-1Ra may play a role in the association between obesity, stress and cardiovascular health. |
| doi_str_mv | 10.1016/j.biopsycho.2010.02.010 |
| format | Article |
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Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptor antagonist (IL-1Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. Our findings suggest that the cytokines leptin and IL-1Ra may play a role in the association between obesity, stress and cardiovascular health.</description><identifier>ISSN: 0301-0511</identifier><identifier>EISSN: 1873-6246</identifier><identifier>DOI: 10.1016/j.biopsycho.2010.02.010</identifier><identifier>PMID: 20193730</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adiposity ; Adolescent ; Adult ; Analysis of Variance ; Blood Pressure - physiology ; Body Mass Index ; Cardiovascular reactivity ; Cytokines ; Cytokines - blood ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Heart Rate - physiology ; Humans ; Hydrocortisone - metabolism ; Interleukin 1 Receptor Antagonist Protein - blood ; Leptin ; Leptin - blood ; Neuropsychological Tests ; Psychological stress ; Saliva - metabolism ; Stress, Psychological - blood ; Stress, Psychological - physiopathology ; Time Factors ; Young Adult</subject><ispartof>Biological psychology, 2011-02, Vol.86 (2), p.114-120</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. 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Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptor antagonist (IL-1Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. Our findings suggest that the cytokines leptin and IL-1Ra may play a role in the association between obesity, stress and cardiovascular health.</description><subject>Adiposity</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Blood Pressure - physiology</subject><subject>Body Mass Index</subject><subject>Cardiovascular reactivity</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Interleukin 1 Receptor Antagonist Protein - blood</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Neuropsychological Tests</subject><subject>Psychological stress</subject><subject>Saliva - metabolism</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - physiopathology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0301-0511</issn><issn>1873-6246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctOAyEUJUaj9fELOjs3Tr3AMDNsTBrjK2niRteEgVtLMx1GmDbp34upNrrq6txwHsA9hFxRGFOg5e1i3Djfx42Z-zGDdApsnOCAjGhd8bxkRXlIRsCB5iAoPSGnMS4A0izEMTlJFskrDiNCJ9b1Prphc5O12A-uy3RnszgEjDELqM3g1onNEjFfLXUXz8nRTLcRL37wjLw_PrzdP-fT16eX-8k0NwLKIZ-hthpooXkhpa1Z3UgthKw4F2k2jbFFNWO2EthIY4FiXVPNwVBEbkrK-Bm52-b2q2aJ1mA3BN2qPrilDhvltVP_mc7N1YdfKw4FE7JIAdc_AcF_rjAOaumiwbbVHfpVVFIUJZRpJ3uVtaBVIStGk7LaKk3wMQac7d5DQX03oxZq14z6bkYBUwmS8_Lvd3a-3yqSYLIVYFrq2mFQ0TjsDFoX0AzKerf3ki9e8qRx</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Brydon, Lena</creator><general>Elsevier B.V</general><general>Elsevier Science B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201102</creationdate><title>Adiposity, leptin and stress reactivity in humans</title><author>Brydon, Lena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-feada014a3499d828b9a559733528bcbcd47f2d75eb9cd01e881a30c1ee3c6123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adiposity</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Blood Pressure - physiology</topic><topic>Body Mass Index</topic><topic>Cardiovascular reactivity</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Interleukin 1 Receptor Antagonist Protein - blood</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Neuropsychological Tests</topic><topic>Psychological stress</topic><topic>Saliva - metabolism</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - physiopathology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brydon, Lena</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological psychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brydon, Lena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiposity, leptin and stress reactivity in humans</atitle><jtitle>Biological psychology</jtitle><addtitle>Biol Psychol</addtitle><date>2011-02</date><risdate>2011</risdate><volume>86</volume><issue>2</issue><spage>114</spage><epage>120</epage><pages>114-120</pages><issn>0301-0511</issn><eissn>1873-6246</eissn><abstract>Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptor antagonist (IL-1Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. 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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adiposity Adolescent Adult Analysis of Variance Blood Pressure - physiology Body Mass Index Cardiovascular reactivity Cytokines Cytokines - blood Enzyme-Linked Immunosorbent Assay - methods Female Heart Rate - physiology Humans Hydrocortisone - metabolism Interleukin 1 Receptor Antagonist Protein - blood Leptin Leptin - blood Neuropsychological Tests Psychological stress Saliva - metabolism Stress, Psychological - blood Stress, Psychological - physiopathology Time Factors Young Adult |
| title | Adiposity, leptin and stress reactivity in humans |
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