Comparison of Pharmacological Modulation of APP Metabolism in Primary Chicken Telencephalic Neurons and in a Human Neuroglioma Cell Line

Sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases and the formation of Aβ peptides are pivotal for Alzheimer's disease. Therefore, a large number of drugs has been developed targeting APP metabolism. However, many pharmacological compounds have been identified in vit...

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Veröffentlicht in:	Journal of molecular neuroscience 2011-03, Vol.43 (3), p.257-267
Hauptverfasser:	Czvitkovich, Stefan, Duller, Stephan, Mathiesen, Else, Lorenzoni, Klaus, Imbimbo, Bruno P., Hutter-Paier, Birgit, Windisch, Manfred, Wronski, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism Biomedical and Life Sciences Biomedicine Calpain - metabolism Cell Biology Cell culture Cell Line, Tumor Cells, Cultured Chickens Culture Media, Conditioned - chemistry Drug testing Glioma - metabolism Humans Metabolism Models, Animal Mutation Neurochemistry Neurology Neurons - cytology Neurons - drug effects Neurons - metabolism Neurosciences Peptides Proteins Proteomics Telencephalon - cytology Telencephalon - metabolism
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