The Molecular Mechanisms of Cervical Ripening Differ between Term and Preterm Birth
Premature cervical ripening can occur by more than one mechanism, and premature ripening associated with preterm birth is not simply an acceleration of term ripening. In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or ear...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2011-03, Vol.152 (3), p.1036-1046 |
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| description | Premature cervical ripening can occur by more than one mechanism, and premature ripening associated with preterm birth is not simply an acceleration of term ripening.
In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening. Tissue morphology, weight, gene expression, and collagen content along with immune cell populations were evaluated. Premature ripening induced by the progesterone receptor antagonist mifepristone results from an acceleration of processes in place during term ripening as well as partial activation of proinflammatory and immunosuppressive processes observed during postpartum repair. In contrast to term or mifepristone-induced preterm ripening, premature ripening induced in an infection model occurs by a distinct mechanism which is dominated by an influx of neutrophils into the cervix, a robust proinflammatory response and increased expression of prostaglandin-cyclooxygenase-endoperoxide synthase 2, important in prostaglandin biosynthesis. Key findings from this study confirm that cervical ripening can be initiated by more than one mechanism and is not necessarily an acceleration of the physiologic process at term. These results will influence current strategies for identifying specific etiologies of preterm birth and developing subsequent therapies. |
| doi_str_mv | 10.1210/en.2010-1105 |
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In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening. Tissue morphology, weight, gene expression, and collagen content along with immune cell populations were evaluated. Premature ripening induced by the progesterone receptor antagonist mifepristone results from an acceleration of processes in place during term ripening as well as partial activation of proinflammatory and immunosuppressive processes observed during postpartum repair. In contrast to term or mifepristone-induced preterm ripening, premature ripening induced in an infection model occurs by a distinct mechanism which is dominated by an influx of neutrophils into the cervix, a robust proinflammatory response and increased expression of prostaglandin-cyclooxygenase-endoperoxide synthase 2, important in prostaglandin biosynthesis. Key findings from this study confirm that cervical ripening can be initiated by more than one mechanism and is not necessarily an acceleration of the physiologic process at term. These results will influence current strategies for identifying specific etiologies of preterm birth and developing subsequent therapies.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2010-1105</identifier><identifier>PMID: 21209014</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Chevy Chase, MD: Endocrine Society</publisher><subject>Animal models ; Animals ; Biological and medical sciences ; Biosynthesis ; Birth ; Cell activation ; Cervical Ripening - drug effects ; Cervical Ripening - physiology ; Cervix Uteri - pathology ; Diseases of mother, fetus and pregnancy ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Regulation - physiology ; Gynecology. Andrology. Obstetrics ; Hormone Antagonists - pharmacology ; Immune system ; Inflammation ; Leukocytes (neutrophilic) ; Lipopolysaccharides - toxicity ; Medical sciences ; Mice ; Mifepristone ; Mifepristone - pharmacology ; Molecular modelling ; Pregnancy ; Pregnancy. Fetus. Placenta ; Premature Birth ; Progesterone ; Prostaglandin endoperoxide synthase ; Quorum sensing ; Reproduction-Development ; Reverse Transcriptase Polymerase Chain Reaction ; Ripening ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2011-03, Vol.152 (3), p.1036-1046</ispartof><rights>Copyright © 2011 by the Endocrine Society</rights><rights>Copyright © 2011 by the Endocrine Society 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-705ba1768b5f075388837f7a70c6efd0126713791407fcf4f844b4d8c0d1e85e3</citedby><cites>FETCH-LOGICAL-c517t-705ba1768b5f075388837f7a70c6efd0126713791407fcf4f844b4d8c0d1e85e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23916407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21209014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holt, Roxane</creatorcontrib><creatorcontrib>Timmons, Brenda C</creatorcontrib><creatorcontrib>Akgul, Yucel</creatorcontrib><creatorcontrib>Akins, Meredith L</creatorcontrib><creatorcontrib>Mahendroo, Mala</creatorcontrib><title>The Molecular Mechanisms of Cervical Ripening Differ between Term and Preterm Birth</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Premature cervical ripening can occur by more than one mechanism, and premature ripening associated with preterm birth is not simply an acceleration of term ripening.
In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening. Tissue morphology, weight, gene expression, and collagen content along with immune cell populations were evaluated. Premature ripening induced by the progesterone receptor antagonist mifepristone results from an acceleration of processes in place during term ripening as well as partial activation of proinflammatory and immunosuppressive processes observed during postpartum repair. In contrast to term or mifepristone-induced preterm ripening, premature ripening induced in an infection model occurs by a distinct mechanism which is dominated by an influx of neutrophils into the cervix, a robust proinflammatory response and increased expression of prostaglandin-cyclooxygenase-endoperoxide synthase 2, important in prostaglandin biosynthesis. Key findings from this study confirm that cervical ripening can be initiated by more than one mechanism and is not necessarily an acceleration of the physiologic process at term. These results will influence current strategies for identifying specific etiologies of preterm birth and developing subsequent therapies.</description><subject>Animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Birth</subject><subject>Cell activation</subject><subject>Cervical Ripening - drug effects</subject><subject>Cervical Ripening - physiology</subject><subject>Cervix Uteri - pathology</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mifepristone</subject><subject>Mifepristone - pharmacology</subject><subject>Molecular modelling</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Premature Birth</subject><subject>Progesterone</subject><subject>Prostaglandin endoperoxide synthase</subject><subject>Quorum sensing</subject><subject>Reproduction-Development</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ripening</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1v1DAQxS0EotvCjTOyhFAvpMzETpxcKsHyKbUCwXK2HGfcdbXrBDsp4r_Hq11akOBkj-anN2_mMfYE4QxLhJcUzkpAKBChuscW2MqqUKjgPlsAoChUWaojdpzSdS6llOIhOyqxhDZXC_Z1tSZ-OWzIzhsT-SXZtQk-bRMfHF9SvPHWbPgXP1Lw4Yq_8c5R5B1NP4gCX1HcchN6_jnStPu_9nFaP2IPnNkkenx4T9i3d29Xyw_Fxaf3H5evLgpboZoKBVVnUNVNVzlQlWiaRiinjAJbk-sBy1qhUC1KUM466RopO9k3FnqkpiJxws73uuPcbam3FKZoNnqMfmviTz0Yr__uBL_WV8ONFiABqioLPDsIxOH7TGnS18McQ_asBQqoscVSZerFnrJxSCmSu52AoHcRaAp6F4HeRZDxp3-6uoV_3zwDzw-ASfm4LppgfbrjRIt1Xjlzp3tumMf_jSwOI8WepNAPNvpAY6SU7rb5p9FfquWqhA</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Holt, Roxane</creator><creator>Timmons, Brenda C</creator><creator>Akgul, Yucel</creator><creator>Akins, Meredith L</creator><creator>Mahendroo, Mala</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>The Molecular Mechanisms of Cervical Ripening Differ between Term and Preterm Birth</title><author>Holt, Roxane ; Timmons, Brenda C ; Akgul, Yucel ; Akins, Meredith L ; Mahendroo, Mala</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-705ba1768b5f075388837f7a70c6efd0126713791407fcf4f844b4d8c0d1e85e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biosynthesis</topic><topic>Birth</topic><topic>Cell activation</topic><topic>Cervical Ripening - drug effects</topic><topic>Cervical Ripening - physiology</topic><topic>Cervix Uteri - pathology</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mifepristone</topic><topic>Mifepristone - pharmacology</topic><topic>Molecular modelling</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature Birth</topic><topic>Progesterone</topic><topic>Prostaglandin endoperoxide synthase</topic><topic>Quorum sensing</topic><topic>Reproduction-Development</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Ripening</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holt, Roxane</creatorcontrib><creatorcontrib>Timmons, Brenda C</creatorcontrib><creatorcontrib>Akgul, Yucel</creatorcontrib><creatorcontrib>Akins, Meredith L</creatorcontrib><creatorcontrib>Mahendroo, Mala</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holt, Roxane</au><au>Timmons, Brenda C</au><au>Akgul, Yucel</au><au>Akins, Meredith L</au><au>Mahendroo, Mala</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Molecular Mechanisms of Cervical Ripening Differ between Term and Preterm Birth</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>152</volume><issue>3</issue><spage>1036</spage><epage>1046</epage><pages>1036-1046</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Premature cervical ripening can occur by more than one mechanism, and premature ripening associated with preterm birth is not simply an acceleration of term ripening.
In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening. Tissue morphology, weight, gene expression, and collagen content along with immune cell populations were evaluated. Premature ripening induced by the progesterone receptor antagonist mifepristone results from an acceleration of processes in place during term ripening as well as partial activation of proinflammatory and immunosuppressive processes observed during postpartum repair. In contrast to term or mifepristone-induced preterm ripening, premature ripening induced in an infection model occurs by a distinct mechanism which is dominated by an influx of neutrophils into the cervix, a robust proinflammatory response and increased expression of prostaglandin-cyclooxygenase-endoperoxide synthase 2, important in prostaglandin biosynthesis. Key findings from this study confirm that cervical ripening can be initiated by more than one mechanism and is not necessarily an acceleration of the physiologic process at term. These results will influence current strategies for identifying specific etiologies of preterm birth and developing subsequent therapies.</abstract><cop>Chevy Chase, MD</cop><pub>Endocrine Society</pub><pmid>21209014</pmid><doi>10.1210/en.2010-1105</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animal models Animals Biological and medical sciences Biosynthesis Birth Cell activation Cervical Ripening - drug effects Cervical Ripening - physiology Cervix Uteri - pathology Diseases of mother, fetus and pregnancy Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - physiology Gynecology. Andrology. Obstetrics Hormone Antagonists - pharmacology Immune system Inflammation Leukocytes (neutrophilic) Lipopolysaccharides - toxicity Medical sciences Mice Mifepristone Mifepristone - pharmacology Molecular modelling Pregnancy Pregnancy. Fetus. Placenta Premature Birth Progesterone Prostaglandin endoperoxide synthase Quorum sensing Reproduction-Development Reverse Transcriptase Polymerase Chain Reaction Ripening Vertebrates: endocrinology |
| title | The Molecular Mechanisms of Cervical Ripening Differ between Term and Preterm Birth |
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