Gene expression profiles of human melanoma cells with different invasive potential reveal TSPAN8 as a novel mediator of invasion

Background: Metastatic melanoma requires early detection, being treatment resistant. However, the earliest events of melanoma metastasis, and especially of dermal invasion, remain ill defined. Results and methods: Gene expression profiles of two clonal subpopulations, selected from the same human me...

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Veröffentlicht in:	British journal of cancer 2011-01, Vol.104 (1), p.155-165
Hauptverfasser:	Berthier-Vergnes, O, Kharbili, M El, de la Fouchardière, A, Pointecouteau, T, Verrando, P, Wierinckx, A, Lachuer, J, Le Naour, F, Lamartine, J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 631/67/1857 631/80/84/2336 692/699/67/1813/1634 Antigens, Neoplasm Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Apoptosis Biochemistry, Molecular Biology Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Cell Movement Cell Proliferation Cloning Dermatology Drug Resistance Epidemiology Flow Cytometry Gene expression Gene Expression Profiling Humans Immunoenzyme Techniques Life Sciences Lymphatic Metastasis Medical research Medical sciences Melanocytes Melanocytes - metabolism Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Membrane Glycoproteins Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Metastasis Molecular Diagnostics Molecular Medicine Neoplasm Invasiveness Oligonucleotide Array Sequence Analysis Oncology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger RNA, Messenger - genetics RNA, Small Interfering RNA, Small Interfering - genetics Skin Neoplasms Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Spheroids, Cellular Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Tetraspanins Tumor Cells, Cultured Tumor Markers, Biological Tumors Tumors of the skin and soft tissue. Premalignant lesions
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