CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr Viral DNA
Lymphoproliferative disease of granular lymphocytes (LDGL) is a heterogeneous disorder and the pathogenesis is likely to be complex. Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate the relationship between EBV infection and the pathogenesis of LDGL, we conducte...
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| Veröffentlicht in: | The Journal of clinical investigation 1989-07, Vol.84 (1), p.51-55 |
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| container_title | The Journal of clinical investigation |
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| creator | KAWA-HA, K ISHIHARA, S NINOMIYA, T YUMURA-YAGI, K HARA, J MURAYAMA, F TAWA, A HIRAI, K |
| description | Lymphoproliferative disease of granular lymphocytes (LDGL) is a heterogeneous disorder and the pathogenesis is likely to be complex. Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate the relationship between EBV infection and the pathogenesis of LDGL, we conducted a survey for EBV DNA sequences by Southern blot analysis of DNA obtained from the peripheral blood of seven patients with LDGL, including one with CAEBV infection. Interestingly, EBV DNA was detected in the sample from the patient with CAEBV infection, and in the samples from four other patients with CD3-LDGL. Moreover, a single band for the joined termini of the EBV genome was demonstrated in two samples, suggesting a clonal disorder of those LDGL. These findings strongly suggest that EBV may play a pathogenic role in some cases of LDGL. |
| doi_str_mv | 10.1172/jci114168 |
| format | Article |
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Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate the relationship between EBV infection and the pathogenesis of LDGL, we conducted a survey for EBV DNA sequences by Southern blot analysis of DNA obtained from the peripheral blood of seven patients with LDGL, including one with CAEBV infection. Interestingly, EBV DNA was detected in the sample from the patient with CAEBV infection, and in the samples from four other patients with CD3-LDGL. Moreover, a single band for the joined termini of the EBV genome was demonstrated in two samples, suggesting a clonal disorder of those LDGL. These findings strongly suggest that EBV may play a pathogenic role in some cases of LDGL.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/jci114168</identifier><identifier>PMID: 2544630</identifier><identifier>CODEN: JCINAO</identifier><language>eng</language><publisher>Ann Arbor, MI: American Society for Clinical Investigation</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies, Viral - immunology ; Antigens, Differentiation, T-Lymphocyte - immunology ; Antigens, Viral - immunology ; Biological and medical sciences ; Blotting, Southern ; Capsid - immunology ; CD3 Complex ; Child ; Chronic Disease ; DNA, Viral - analysis ; DNA, Viral - genetics ; Epstein-Barr virus ; Female ; Granulocytes - immunology ; Granulocytes - microbiology ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - immunology ; Humans ; Lymphoproliferative Disorders - immunology ; Lymphoproliferative Disorders - microbiology ; Male ; Medical sciences ; Middle Aged ; Nucleic Acid Hybridization ; Other diseases. Hematologic involvement in other diseases ; Receptors, Antigen, T-Cell - genetics ; Receptors, Antigen, T-Cell - immunology</subject><ispartof>The Journal of clinical investigation, 1989-07, Vol.84 (1), p.51-55</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-51a8fcfb679f1677f99cc21400b2f6196cd1059eb66ef9a5c6ed0d4428ea19673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC303951/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC303951/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7345423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2544630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAWA-HA, K</creatorcontrib><creatorcontrib>ISHIHARA, S</creatorcontrib><creatorcontrib>NINOMIYA, T</creatorcontrib><creatorcontrib>YUMURA-YAGI, K</creatorcontrib><creatorcontrib>HARA, J</creatorcontrib><creatorcontrib>MURAYAMA, F</creatorcontrib><creatorcontrib>TAWA, A</creatorcontrib><creatorcontrib>HIRAI, K</creatorcontrib><title>CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr Viral DNA</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>Lymphoproliferative disease of granular lymphocytes (LDGL) is a heterogeneous disorder and the pathogenesis is likely to be complex. Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate the relationship between EBV infection and the pathogenesis of LDGL, we conducted a survey for EBV DNA sequences by Southern blot analysis of DNA obtained from the peripheral blood of seven patients with LDGL, including one with CAEBV infection. Interestingly, EBV DNA was detected in the sample from the patient with CAEBV infection, and in the samples from four other patients with CD3-LDGL. Moreover, a single band for the joined termini of the EBV genome was demonstrated in two samples, suggesting a clonal disorder of those LDGL. These findings strongly suggest that EBV may play a pathogenic role in some cases of LDGL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - immunology</subject><subject>Antigens, Differentiation, T-Lymphocyte - immunology</subject><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Capsid - immunology</subject><subject>CD3 Complex</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - genetics</subject><subject>Epstein-Barr virus</subject><subject>Female</subject><subject>Granulocytes - immunology</subject><subject>Granulocytes - microbiology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Humans</subject><subject>Lymphoproliferative Disorders - immunology</subject><subject>Lymphoproliferative Disorders - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nucleic Acid Hybridization</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhwAdAygFV4hDq_44PHMq2QKsKLsDVcpzx1lXWDna20n77utpoBSdOI837zZsnPYTeEvyREEXP710ghBPZPUMrIkTXdpR1z9EKY0parVj3Er0q5R5jwrngJ-iECs4lwyvUry9ZG2Fj5_AAzbjfTndpymkMHvJhN4QCtkCTfLPJNu5GmxfO7WcojUtxtiGGuGmupjJDiO1nm3PzO2Q7NpffL16jF96OBd4s8xT9-nL1c_2tvf3x9Xp9cds6rsXcCmI773wvlfZEKuW1do4SjnFPvSRauoFgoaGXEry2wkkY8MA57cBWVbFT9OngO-36LQwO4lwTmCmHrc17k2ww_yox3JlNejAMMy1IvT9b7nP6s4Mym20oDsbRRki7YpTGQtU__wWJoLoaPjl-OIAup1Iy-GMYgs1TceZmfX0orrLv_k5_JJemqv5-0W1xdvS1ChfKEVOsFksZewSOpKHw</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>KAWA-HA, K</creator><creator>ISHIHARA, S</creator><creator>NINOMIYA, T</creator><creator>YUMURA-YAGI, K</creator><creator>HARA, J</creator><creator>MURAYAMA, F</creator><creator>TAWA, A</creator><creator>HIRAI, K</creator><general>American Society for Clinical Investigation</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890701</creationdate><title>CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr Viral DNA</title><author>KAWA-HA, K ; ISHIHARA, S ; NINOMIYA, T ; YUMURA-YAGI, K ; HARA, J ; MURAYAMA, F ; TAWA, A ; HIRAI, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-51a8fcfb679f1677f99cc21400b2f6196cd1059eb66ef9a5c6ed0d4428ea19673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Viral - immunology</topic><topic>Antigens, Differentiation, T-Lymphocyte - immunology</topic><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Capsid - immunology</topic><topic>CD3 Complex</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>DNA, Viral - analysis</topic><topic>DNA, Viral - genetics</topic><topic>Epstein-Barr virus</topic><topic>Female</topic><topic>Granulocytes - immunology</topic><topic>Granulocytes - microbiology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Humans</topic><topic>Lymphoproliferative Disorders - immunology</topic><topic>Lymphoproliferative Disorders - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nucleic Acid Hybridization</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWA-HA, K</creatorcontrib><creatorcontrib>ISHIHARA, S</creatorcontrib><creatorcontrib>NINOMIYA, T</creatorcontrib><creatorcontrib>YUMURA-YAGI, K</creatorcontrib><creatorcontrib>HARA, J</creatorcontrib><creatorcontrib>MURAYAMA, F</creatorcontrib><creatorcontrib>TAWA, A</creatorcontrib><creatorcontrib>HIRAI, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWA-HA, K</au><au>ISHIHARA, S</au><au>NINOMIYA, T</au><au>YUMURA-YAGI, K</au><au>HARA, J</au><au>MURAYAMA, F</au><au>TAWA, A</au><au>HIRAI, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr Viral DNA</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>84</volume><issue>1</issue><spage>51</spage><epage>55</epage><pages>51-55</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><coden>JCINAO</coden><abstract>Lymphoproliferative disease of granular lymphocytes (LDGL) is a heterogeneous disorder and the pathogenesis is likely to be complex. Some patients with chronic active EBV (CAEBV) infection also have LDGL. To investigate the relationship between EBV infection and the pathogenesis of LDGL, we conducted a survey for EBV DNA sequences by Southern blot analysis of DNA obtained from the peripheral blood of seven patients with LDGL, including one with CAEBV infection. Interestingly, EBV DNA was detected in the sample from the patient with CAEBV infection, and in the samples from four other patients with CD3-LDGL. Moreover, a single band for the joined termini of the EBV genome was demonstrated in two samples, suggesting a clonal disorder of those LDGL. These findings strongly suggest that EBV may play a pathogenic role in some cases of LDGL.</abstract><cop>Ann Arbor, MI</cop><pub>American Society for Clinical Investigation</pub><pmid>2544630</pmid><doi>10.1172/jci114168</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Antibodies, Viral - immunology Antigens, Differentiation, T-Lymphocyte - immunology Antigens, Viral - immunology Biological and medical sciences Blotting, Southern Capsid - immunology CD3 Complex Child Chronic Disease DNA, Viral - analysis DNA, Viral - genetics Epstein-Barr virus Female Granulocytes - immunology Granulocytes - microbiology Hematologic and hematopoietic diseases Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Humans Lymphoproliferative Disorders - immunology Lymphoproliferative Disorders - microbiology Male Medical sciences Middle Aged Nucleic Acid Hybridization Other diseases. Hematologic involvement in other diseases Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology |
| title | CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr Viral DNA |
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