Surfactant Protein A (SP-A)-mediated Clearance of Staphylococcus aureus Involves Binding of SP-A to the Staphylococcal Adhesin Eap and the Macrophage Receptors SP-A Receptor 210 and Scavenger Receptor Class A

Staphylococcus aureus causes life-threatening pneumonia in hospitals and deadly superinfection during viral influenza. The current study investigated the role of surfactant protein A (SP-A) in opsonization and clearance of S. aureus. Previous studies showed that SP-A mediates phagocytosis via the SP...

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Veröffentlicht in:	The Journal of biological chemistry 2011-02, Vol.286 (6), p.4854-4870
Hauptverfasser:	Sever-Chroneos, Zvjezdana, Krupa, Agnieszka, Davis, Jeremy, Hasan, Misbah, Yang, Ching-Hui, Szeliga, Jacek, Herrmann, Mathias, Hussain, Muzafar, Geisbrecht, Brian V., Kobzik, Lester, Chroneos, Zissis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Animals Chlorocebus aethiops COS Cells Humans Immunology Inflammation Innate Immunity Lung Lung - metabolism Macrophage Macrophages, Alveolar - metabolism Macrophages, Peritoneal - metabolism Mice Mice, Knockout Phagocytosis - physiology Pneumonia, Staphylococcal - genetics Pneumonia, Staphylococcal - metabolism Pulmonary Surfactant Pulmonary Surfactant-Associated Protein A - genetics Pulmonary Surfactant-Associated Protein A - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus aureus - metabolism
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