Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut
Residing within the intestine is a large community of commensal organisms collectively termed the microbiota. This community generates a complex nutrient environment by breaking down indigestible food products into metabolites that are used by both the host and the microbiota. Both the invading inte...
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| Veröffentlicht in: | Current opinion in microbiology 2011-02, Vol.14 (1), p.92-98 |
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| creator | Keeney, Kristie M Finlay, B Brett |
| description | Residing within the intestine is a large community of commensal organisms collectively termed the microbiota. This community generates a complex nutrient environment by breaking down indigestible food products into metabolites that are used by both the host and the microbiota. Both the invading intestinal pathogen and the microbiota compete for these metabolites, which can shape both the composition of the flora, as well as susceptibility to infection. After infection is established, pathogen mediated inflammation alters the composition of the microbiota, which further shifts the makeup of metabolites in the gastrointestinal tract. A greater understanding of the interplay between the microbiota, the metabolites they generate, and susceptibility to enteric disease will enable the discovery of novel therapies against infectious disease. |
| doi_str_mv | 10.1016/j.mib.2010.12.012 |
| format | Article |
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| ispartof | Current opinion in microbiology, 2011-02, Vol.14 (1), p.92-98 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | animal diseases Animals Bacteria - pathogenicity Biological and medical sciences commensalism Commensals Digestive tract enteropathogens Food foods Fundamental and applied biological sciences. Psychology Gastrointestinal tract Gastrointestinal Tract - microbiology hosts Humans Infection Infectious diseases Inflammation Intestine intestines Metabolites Metagenome - physiology microbial communities Microbiology microorganisms Nutrients Nutritional Physiological Phenomena Pathogens Pathology Reviews Virulence - genetics |
| title | Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut |
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