Crystal structure of a γδ T-cell receptor specific for the human MHC class I homolog MICA

γδ T cells play important roles in bridging innate and adaptive immunity, but their recognition mechanisms remain poorly understood. Human γδ T cells of the Vδ1 subset predominate in intestinal epithelia and respond to MICA and MICB (MHC class I chain-related, A and B; MIC) self-antigens, mediating...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-02, Vol.108 (6), p.2414-2419
Hauptverfasser:	Xu, Bin, Pizarro, Juan C, Holmes, Margaret A, McBeth, Christine, Groh, Veronika, Spies, Thomas, Strong, Roland K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological Sciences Crystal structure Ligands Mica Mice Molecular structure Molecules Receptors T cell antigen receptors T lymphocytes
Online-Zugang:	Volltext
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