25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth
Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear. Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal f...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2011-01, Vol.96 (1), p.E89-E98 |
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| creator | Breen, M. E Laing, E. M Hall, D. B Hausman, D. B Taylor, R. G Isales, C. M Ding, K. H Pollock, N. K Hamrick, M. W Baile, C. A Lewis, R. D |
| description | Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear.
Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4–8 yr at baseline) over a period of up to 9 yr.
Design: The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes.
Results: IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R2 = 0.874 vs. 0.809), proximal femur (R2 = 0.847 vs. 0.771), radius (R2 = 0.812 vs. 0.759), and lumbar spine (R2 = 0.759 vs. 0.698). The rate of BMC accrual was positively associated with changes in IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I.
Conclusions: These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual.
Both 25(OH)D and IGF-I impact bone mineral accrual; however, the positive association of IGF-I is greater than the negative association of 25(OH)D on BMC accrual. |
| doi_str_mv | 10.1210/jc.2010-0595 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3038478</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>904464440</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-665916e4b3b56af73beccc44571b250ca05d163345a0f9e1ffaf3a950151be173</originalsourceid><addsrcrecordid>eNqFkc1vEzEQxS0EoqFw44z2xiUu46_d-IJUCm0jBXEBCU6W1zvbOmzs1N4t5L_HUUIFEhKnOcxvnt68R8hLBmeMM3izdmccGFBQWj0iM6alog3TzWMyA-CM6oZ_PSHPcl4DMCmVeEpOOOiaA29m5BtX9HrXpfhzd-9Hu_Ghej-vliFPgw905b9jdZXij_G2urRujIku55UNXfUuBqw--oDJDtW5c2kqs5uSDzfHg-fkSW-HjC-O85R8ufzw-eKarj5dLS_OV9RJpUda10qzGmUrWlXbvhEtOueKz4a1XIGzoDpWCyGVhV4j63vbC6sVMMVaZI04JW8Putup3WDnMIzFk9kmv7FpZ6L15u9N8LfmJt4bAWIhm0UReH0USPFuwjyajc8Oh8EGjFM2GqSspZTwX3LB-UKXZGUh5wfSpZhzwv7BDwOzr82sndnXZva1FfzVnz88wL97KoA4ABi66ErKuE2Ys1nHKYWS7r9lfwGbSqOh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>822899624</pqid></control><display><type>article</type><title>25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Breen, M. E ; Laing, E. M ; Hall, D. B ; Hausman, D. B ; Taylor, R. G ; Isales, C. M ; Ding, K. H ; Pollock, N. K ; Hamrick, M. W ; Baile, C. A ; Lewis, R. D</creator><creatorcontrib>Breen, M. E ; Laing, E. M ; Hall, D. B ; Hausman, D. B ; Taylor, R. G ; Isales, C. M ; Ding, K. H ; Pollock, N. K ; Hamrick, M. W ; Baile, C. A ; Lewis, R. D</creatorcontrib><description>Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear.
Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4–8 yr at baseline) over a period of up to 9 yr.
Design: The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes.
Results: IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R2 = 0.874 vs. 0.809), proximal femur (R2 = 0.847 vs. 0.771), radius (R2 = 0.812 vs. 0.759), and lumbar spine (R2 = 0.759 vs. 0.698). The rate of BMC accrual was positively associated with changes in IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I.
Conclusions: These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual.
Both 25(OH)D and IGF-I impact bone mineral accrual; however, the positive association of IGF-I is greater than the negative association of 25(OH)D on BMC accrual.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2010-0595</identifier><identifier>PMID: 20962027</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Analysis of Variance ; Body Composition ; Bone Density - physiology ; Calcification, Physiologic - physiology ; Child ; Child, Preschool ; Diet ; Female ; Humans ; Insulin-Like Growth Factor I - metabolism ; Linear Models ; Original ; Prospective Studies ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>The journal of clinical endocrinology and metabolism, 2011-01, Vol.96 (1), p.E89-E98</ispartof><rights>Copyright © 2011 by The Endocrine Society 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-665916e4b3b56af73beccc44571b250ca05d163345a0f9e1ffaf3a950151be173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20962027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Breen, M. E</creatorcontrib><creatorcontrib>Laing, E. M</creatorcontrib><creatorcontrib>Hall, D. B</creatorcontrib><creatorcontrib>Hausman, D. B</creatorcontrib><creatorcontrib>Taylor, R. G</creatorcontrib><creatorcontrib>Isales, C. M</creatorcontrib><creatorcontrib>Ding, K. H</creatorcontrib><creatorcontrib>Pollock, N. K</creatorcontrib><creatorcontrib>Hamrick, M. W</creatorcontrib><creatorcontrib>Baile, C. A</creatorcontrib><creatorcontrib>Lewis, R. D</creatorcontrib><title>25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear.
Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4–8 yr at baseline) over a period of up to 9 yr.
Design: The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes.
Results: IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R2 = 0.874 vs. 0.809), proximal femur (R2 = 0.847 vs. 0.771), radius (R2 = 0.812 vs. 0.759), and lumbar spine (R2 = 0.759 vs. 0.698). The rate of BMC accrual was positively associated with changes in IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I.
Conclusions: These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual.
Both 25(OH)D and IGF-I impact bone mineral accrual; however, the positive association of IGF-I is greater than the negative association of 25(OH)D on BMC accrual.</description><subject>Analysis of Variance</subject><subject>Body Composition</subject><subject>Bone Density - physiology</subject><subject>Calcification, Physiologic - physiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diet</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Linear Models</subject><subject>Original</subject><subject>Prospective Studies</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EoqFw44z2xiUu46_d-IJUCm0jBXEBCU6W1zvbOmzs1N4t5L_HUUIFEhKnOcxvnt68R8hLBmeMM3izdmccGFBQWj0iM6alog3TzWMyA-CM6oZ_PSHPcl4DMCmVeEpOOOiaA29m5BtX9HrXpfhzd-9Hu_Ghej-vliFPgw905b9jdZXij_G2urRujIku55UNXfUuBqw--oDJDtW5c2kqs5uSDzfHg-fkSW-HjC-O85R8ufzw-eKarj5dLS_OV9RJpUda10qzGmUrWlXbvhEtOueKz4a1XIGzoDpWCyGVhV4j63vbC6sVMMVaZI04JW8Putup3WDnMIzFk9kmv7FpZ6L15u9N8LfmJt4bAWIhm0UReH0USPFuwjyajc8Oh8EGjFM2GqSspZTwX3LB-UKXZGUh5wfSpZhzwv7BDwOzr82sndnXZva1FfzVnz88wL97KoA4ABi66ErKuE2Ys1nHKYWS7r9lfwGbSqOh</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Breen, M. E</creator><creator>Laing, E. M</creator><creator>Hall, D. B</creator><creator>Hausman, D. B</creator><creator>Taylor, R. G</creator><creator>Isales, C. M</creator><creator>Ding, K. H</creator><creator>Pollock, N. K</creator><creator>Hamrick, M. W</creator><creator>Baile, C. A</creator><creator>Lewis, R. D</creator><general>Endocrine Society</general><general>The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth</title><author>Breen, M. E ; Laing, E. M ; Hall, D. B ; Hausman, D. B ; Taylor, R. G ; Isales, C. M ; Ding, K. H ; Pollock, N. K ; Hamrick, M. W ; Baile, C. A ; Lewis, R. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-665916e4b3b56af73beccc44571b250ca05d163345a0f9e1ffaf3a950151be173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analysis of Variance</topic><topic>Body Composition</topic><topic>Bone Density - physiology</topic><topic>Calcification, Physiologic - physiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diet</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Linear Models</topic><topic>Original</topic><topic>Prospective Studies</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Breen, M. E</creatorcontrib><creatorcontrib>Laing, E. M</creatorcontrib><creatorcontrib>Hall, D. B</creatorcontrib><creatorcontrib>Hausman, D. B</creatorcontrib><creatorcontrib>Taylor, R. G</creatorcontrib><creatorcontrib>Isales, C. M</creatorcontrib><creatorcontrib>Ding, K. H</creatorcontrib><creatorcontrib>Pollock, N. K</creatorcontrib><creatorcontrib>Hamrick, M. W</creatorcontrib><creatorcontrib>Baile, C. A</creatorcontrib><creatorcontrib>Lewis, R. D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Breen, M. E</au><au>Laing, E. M</au><au>Hall, D. B</au><au>Hausman, D. B</au><au>Taylor, R. G</au><au>Isales, C. M</au><au>Ding, K. H</au><au>Pollock, N. K</au><au>Hamrick, M. W</au><au>Baile, C. A</au><au>Lewis, R. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>96</volume><issue>1</issue><spage>E89</spage><epage>E98</epage><pages>E89-E98</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear.
Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4–8 yr at baseline) over a period of up to 9 yr.
Design: The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes.
Results: IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R2 = 0.874 vs. 0.809), proximal femur (R2 = 0.847 vs. 0.771), radius (R2 = 0.812 vs. 0.759), and lumbar spine (R2 = 0.759 vs. 0.698). The rate of BMC accrual was positively associated with changes in IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I.
Conclusions: These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual.
Both 25(OH)D and IGF-I impact bone mineral accrual; however, the positive association of IGF-I is greater than the negative association of 25(OH)D on BMC accrual.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>20962027</pmid><doi>10.1210/jc.2010-0595</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2011-01, Vol.96 (1), p.E89-E98 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Analysis of Variance Body Composition Bone Density - physiology Calcification, Physiologic - physiology Child Child, Preschool Diet Female Humans Insulin-Like Growth Factor I - metabolism Linear Models Original Prospective Studies Vitamin D - analogs & derivatives Vitamin D - blood |
| title | 25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth |
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