Application of physiologically based modelling and transcriptomics to probe the systems toxicology of aldicarb for Caenorhabditis elegans (Maupas 1900)

The toxicity of aldicarb on movement, life cycle, population growth rate and resource allocation, and the gene expression changes underpinning these effects, were investigated for Caenorhabditis elegans. A clear effect of aldicarb on nematode movement was found suggesting that this pesticide acts as...

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Veröffentlicht in:	Ecotoxicology (London) 2011-03, Vol.20 (2), p.397-408
Hauptverfasser:	Wren, Jodie F, Kille, Peter, Spurgeon, David J, Swain, Suresh, Sturzenbaum, Stephen R, Jager, Tjalling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Aldicarb Aldicarb - toxicity Amino acids Animals Biological effects Biotransformation Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Carbamates Cholinesterase Inhibitors - toxicity cytochrome P-450 DEBtox Deoxyribonucleic acid DNA Earth and Environmental Science Ecology Ecotoxicology Environment Environmental Management Fatty acids Gene expression Gene Expression - drug effects Gene Expression Profiling Growth rate Insecticides - toxicity Investigations Life Cycle Stages - drug effects Life cycles Life history Life-span Maintenance costs Metabolism Modelling Models, Biological Nematoda Nervous System - drug effects Pesticides Physiological aspects Population growth protein metabolism reproduction Resource allocation Toxicology
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