A combined fMRI study of typed spelling and reading
In this study we employed a novel technique to examine the neural basis of written spelling by having subjects touch-type single words on an fMRI compatible QWERTY keyboard. Additionally, in the same group of participants we determined if task-related signal changes associated with typed spelling we...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2011-03, Vol.55 (2), p.750-762 |
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| creator | Purcell, Jeremy J. Napoliello, Eileen M. Eden, Guinevere F. |
| description | In this study we employed a novel technique to examine the neural basis of written spelling by having subjects touch-type single words on an fMRI compatible QWERTY keyboard. Additionally, in the same group of participants we determined if task-related signal changes associated with typed spelling were also co-localized with or separate from those for reading. Of particular interest were the left inferior frontal gyrus, left inferior parietal lobe as well as an area in the left occipitotemporal cortex termed the Visual Word Form Area (VWFA), each of which have been associated with both spelling and reading. Our results revealed that typed spelling was associated with a left hemisphere network of regions which included the inferior frontal gyrus, intraparietal sulcus, inferior temporal/fusiform gyrus, as well as a region in the superior/middle frontal gyrus, near Exner's area. A conjunction analysis of activation associated with spelling and reading revealed a significant overlap in the left inferior frontal gyrus and occipitotemporal cortex. Interestingly, within the occipitotemporal cortex just lateral and superior to the VWFA we identified an area that was selectively associated with spelling, as revealed by a direct comparison of the two tasks. These results demonstrate that typed spelling activates a predominantly left hemisphere network, a subset of which is functionally relevant to both spelling and reading. Further analysis revealed that the left occipitotemporal cortex contains regions with both conjoint and dissociable patterns of activation for spelling and reading.
► Typed spelling activated a left hemisphere network of language related areas. ► Typed spelling activation was observed near Exner's area. ► Typed spelling and reading activation was co-localized to left IFG and ITG. ► Activity for spelling was found lateral to reading in left occipitotemporal cortex. |
| doi_str_mv | 10.1016/j.neuroimage.2010.11.042 |
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► Typed spelling activated a left hemisphere network of language related areas. ► Typed spelling activation was observed near Exner's area. ► Typed spelling and reading activation was co-localized to left IFG and ITG. ► Activity for spelling was found lateral to reading in left occipitotemporal cortex.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2010.11.042</identifier><identifier>PMID: 21109009</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Brain ; Brain Mapping ; Cerebral Cortex - physiology ; Exner's area ; Female ; fMRI ; Handwriting ; Humans ; Image Interpretation, Computer-Assisted ; Letters ; Magnetic Resonance Imaging ; Male ; Reading ; Semantics ; Spelling ; Studies ; Typing ; VWFA ; Writing ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2011-03, Vol.55 (2), p.750-762</ispartof><rights>2010</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Mar 15, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-2f8ee2af41ca8c8a57e4d2b2cee447db4eb864798951380d11dc42ad110b5f823</citedby><cites>FETCH-LOGICAL-c604t-2f8ee2af41ca8c8a57e4d2b2cee447db4eb864798951380d11dc42ad110b5f823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1549920256?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21109009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Purcell, Jeremy J.</creatorcontrib><creatorcontrib>Napoliello, Eileen M.</creatorcontrib><creatorcontrib>Eden, Guinevere F.</creatorcontrib><title>A combined fMRI study of typed spelling and reading</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>In this study we employed a novel technique to examine the neural basis of written spelling by having subjects touch-type single words on an fMRI compatible QWERTY keyboard. Additionally, in the same group of participants we determined if task-related signal changes associated with typed spelling were also co-localized with or separate from those for reading. Of particular interest were the left inferior frontal gyrus, left inferior parietal lobe as well as an area in the left occipitotemporal cortex termed the Visual Word Form Area (VWFA), each of which have been associated with both spelling and reading. Our results revealed that typed spelling was associated with a left hemisphere network of regions which included the inferior frontal gyrus, intraparietal sulcus, inferior temporal/fusiform gyrus, as well as a region in the superior/middle frontal gyrus, near Exner's area. A conjunction analysis of activation associated with spelling and reading revealed a significant overlap in the left inferior frontal gyrus and occipitotemporal cortex. Interestingly, within the occipitotemporal cortex just lateral and superior to the VWFA we identified an area that was selectively associated with spelling, as revealed by a direct comparison of the two tasks. These results demonstrate that typed spelling activates a predominantly left hemisphere network, a subset of which is functionally relevant to both spelling and reading. Further analysis revealed that the left occipitotemporal cortex contains regions with both conjoint and dissociable patterns of activation for spelling and reading.
► Typed spelling activated a left hemisphere network of language related areas. ► Typed spelling activation was observed near Exner's area. ► Typed spelling and reading activation was co-localized to left IFG and ITG. ► Activity for spelling was found lateral to reading in left occipitotemporal cortex.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - physiology</subject><subject>Exner's area</subject><subject>Female</subject><subject>fMRI</subject><subject>Handwriting</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Letters</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Reading</subject><subject>Semantics</subject><subject>Spelling</subject><subject>Studies</subject><subject>Typing</subject><subject>VWFA</subject><subject>Writing</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtr3DAQx0VJaNK0X6EYesjJW40s2fKlkIQ-AgmB0J6FLI23WnaljWQH9tt3lk3TxyWnGY1-8_wzVgFfAIf242oRcc4pbOwSF4Lvw7DgUrxip8B7VfeqE0d7XzW1BuhP2JtSVpzzHqR-zU4EEEavU9ZcVC5thhDRV-Pt_XVVptnvqjRW025LsbLF9TrEZWWjrzJaT_5bdjzadcF3T_aM_fjy-fvVt_rm7uv11cVN7Voup1qMGlHYUYKz2mmrOpReDMIhStn5QeKgW9n1ulfQaO4BvJPCkuWDGrVoztinQ93tPGzQO4xTtmuzzbR33plkg_n3J4afZpkeTcMb1TUNFTh_KpDTw4xlMptQHC1kI6a5GGov6VxCv0wqrlole0Xkh__IVZpzpDsYIKAXXKiWKH2gXE6lZByfpwZu9hKalfkjodlLaAAMSUip7__e-jnxt2YEXB4ApNs_BsymuIDRoQ8Z3WR8Ci93-QW2AbEq</recordid><startdate>20110315</startdate><enddate>20110315</enddate><creator>Purcell, Jeremy J.</creator><creator>Napoliello, Eileen M.</creator><creator>Eden, Guinevere F.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><scope>5PM</scope></search><sort><creationdate>20110315</creationdate><title>A combined fMRI study of typed spelling and reading</title><author>Purcell, Jeremy J. ; 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Additionally, in the same group of participants we determined if task-related signal changes associated with typed spelling were also co-localized with or separate from those for reading. Of particular interest were the left inferior frontal gyrus, left inferior parietal lobe as well as an area in the left occipitotemporal cortex termed the Visual Word Form Area (VWFA), each of which have been associated with both spelling and reading. Our results revealed that typed spelling was associated with a left hemisphere network of regions which included the inferior frontal gyrus, intraparietal sulcus, inferior temporal/fusiform gyrus, as well as a region in the superior/middle frontal gyrus, near Exner's area. A conjunction analysis of activation associated with spelling and reading revealed a significant overlap in the left inferior frontal gyrus and occipitotemporal cortex. Interestingly, within the occipitotemporal cortex just lateral and superior to the VWFA we identified an area that was selectively associated with spelling, as revealed by a direct comparison of the two tasks. These results demonstrate that typed spelling activates a predominantly left hemisphere network, a subset of which is functionally relevant to both spelling and reading. Further analysis revealed that the left occipitotemporal cortex contains regions with both conjoint and dissociable patterns of activation for spelling and reading.
► Typed spelling activated a left hemisphere network of language related areas. ► Typed spelling activation was observed near Exner's area. ► Typed spelling and reading activation was co-localized to left IFG and ITG. ► Activity for spelling was found lateral to reading in left occipitotemporal cortex.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21109009</pmid><doi>10.1016/j.neuroimage.2010.11.042</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Brain Brain Mapping Cerebral Cortex - physiology Exner's area Female fMRI Handwriting Humans Image Interpretation, Computer-Assisted Letters Magnetic Resonance Imaging Male Reading Semantics Spelling Studies Typing VWFA Writing Young Adult |
| title | A combined fMRI study of typed spelling and reading |
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