Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila

We have leveraged a Drosophila model relevant to Alzheimer disease (AD) for functional screening of findings from a genome-wide scan for loci associated with a quantitative measure of AD pathology in humans. In six of the 15 genomic regions evaluated, we successfully identified a causal gene for the...

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Veröffentlicht in:	American journal of human genetics 2011-02, Vol.88 (2), p.232-238
Hauptverfasser:	Shulman, Joshua M., Chipendo, Portia, Chibnik, Lori B., Aubin, Cristin, Tran, Dong, Keenan, Brendan T., Kramer, Patricia L., Schneider, Julie A., Bennett, David A., Feany, Mel B., De Jager, Philip L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drosophila Drosophila - genetics Fundamental and applied biological sciences. Psychology General aspects. Genetic counseling Genetic disorders Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome Genome-Wide Association Study Genomics Glucose transporter Glucose Transporter Type 1 - genetics Humans Insects Medical genetics Medical sciences Medical screening Molecular and cellular biology Neurodegenerative diseases Neurofibrillary tangles Neurofibrillary Tangles - genetics Neurofibrillary Tangles - pathology Neurology Neurotoxicity Pathology Phenotype Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci Replication Signal Transduction Tau protein tau Proteins - genetics
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