Tunable Signal Processing in Synthetic MAP Kinase Cascades

The flexibility of MAPK cascade responses enables regulation of a vast array of cell fate decisions, but elucidating the mechanisms underlying this plasticity is difficult in endogenous signaling networks. We constructed insulated mammalian MAPK cascades in yeast to explore how intrinsic and extrins...

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Veröffentlicht in:	Cell 2011-01, Vol.144 (1), p.119-131
Hauptverfasser:	O'Shaughnessy, Ellen C., Palani, Santhosh, Collins, James J., Sarkar, Casim A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans mammals MAP Kinase Signaling System metabolism mitogen-activated protein kinase Models, Biological Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Signal Transduction Synthetic Biology yeasts
Online-Zugang:	Volltext
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