Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients carrying mutations in MPO is variable. Serious microbial infections, especially with Candida species, have been observed in a subset of comple...

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Veröffentlicht in:	Blood 2011-01, Vol.117 (3), p.953-959
Hauptverfasser:	Metzler, Kathleen D., Fuchs, Tobias A., Nauseef, William M., Reumaux, Dominique, Roesler, Joachim, Schulze, Ilka, Wahn, Volker, Papayannopoulos, Venizelos, Zychlinsky, Arturo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Biological and medical sciences Blood Donors Blotting, Western Candida albicans - physiology Cells, Cultured Extracellular Space - drug effects Extracellular Space - immunology Extracellular Space - metabolism Genotype Hematologic and hematopoietic diseases Host-Pathogen Interactions Humans Immunity, Innate - immunology Medical sciences Microscopy, Fluorescence Mutation Neutrophils - immunology Neutrophils - metabolism Neutrophils - microbiology Peroxidase - antagonists & inhibitors Peroxidase - genetics Peroxidase - metabolism Phagocytes, Granulocytes, and Myelopoiesis Tetradecanoylphorbol Acetate - pharmacology
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