Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight ind...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-8
Hauptverfasser: Long, K., Rofiee, M. S., Ahmad, Zuraini, Zakaria, Zainul Amiruddin, Salleh, M. Z., Teh, L. K., Sulaiman, Mohd Roslan, Somchit, M. N.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics
Antioxidants
Coconut oil
Drugs
Fatty acids
Fermented food
Herbal medicine
Laboratory animals
Liver
Liver diseases
Metabolism
Milk
Nutrition research
Paracetamol
Pharmacology
Pharmacy
Rats
Rodents
Vegetable oils
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Zusammenfassung:The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2011/142739