Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice

OBJECTIVE—Atherosclerosis encompasses a conspicuously maladaptive inflammatory response that might involve innate immunity. Here, we compared the role of Toll-like receptor 4 (TLR4) with that of TLR2 in intimal foam cell accumulation and inflammation in apolipoprotein E (ApoE) knockout (KO) mice in...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-01, Vol.31 (1), p.50-57
Hauptverfasser:	Higashimori, Mie, Tatro, Jeffrey B, Moore, Kathryn J, Mendelsohn, Michael E, Galper, Jonas B, Beasley, Debbie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA C-Acetyltransferase - metabolism Animals Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aortic Diseases - genetics Aortic Diseases - metabolism Aortic Diseases - pathology Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chemokine CCL2 - genetics Cholesterol - blood Disease Models, Animal Diseases of the cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Foam Cells - metabolism Foam Cells - pathology Gene Expression Regulation Inflammation Mediators - metabolism Interleukin-1alpha - blood Interleukin-1alpha - genetics Male Medical sciences Mice Mice, Knockout Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) RNA, Messenger - metabolism Signal Transduction Time Factors Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Triglycerides - blood Vascular Cell Adhesion Molecule-1 - genetics
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