A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Enterotoxigenic Bacteroides fragilis, a bacterium from the intestinal flora, may promote colon tumor formation through a pathway that involves Stat3 expression and T helper type 17 immune responses. The intestinal flora may promote colon tumor formation. Here we explore immunologic mechanisms of col...

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Veröffentlicht in:	Nature medicine 2009-09, Vol.15 (9), p.1016-1022
Hauptverfasser:	Housseau, Franck, McAllister, Florencia, Rabizadeh, Shervin, Wu, Xinqun, Huso, David L, Rhee, Ki-Jong, Yen, Hung-Rong, Sears, Cynthia L, Wu, Shaoguang, Albesiano, Emilia, Pardoll, Drew M, Brancati, Frederick L, Wick, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial Toxins - toxicity Bacteroides fragilis Bacteroides fragilis - immunology Bacteroides fragilis - isolation & purification Bacteroides fragilis - pathogenicity Bacteroides Infections - immunology Bacteroides Infections - pathology Biomedical and Life Sciences Biomedicine Cancer Research Carcinogenesis Cellular biology Colitis - etiology Colitis - immunology Colitis - microbiology Colitis - pathology Colon Colon - immunology Colon - microbiology Colon - pathology Colonic Neoplasms - etiology Colonic Neoplasms - immunology Colonic Neoplasms - microbiology Colonic Neoplasms - pathology Colorectal cancer Development and progression Enterotoxins - toxicity Flora Human populations Humans Immune response Immune system Infectious Diseases Interleukin-17 - antagonists & inhibitors Interleukin-17 - metabolism Lymphocyte Activation Lymphocytes Metabolic Diseases Metalloendopeptidases - toxicity Mice Mice, Knockout Mice, Mutant Strains Molecular Medicine Neurosciences Neutralization Tests Pathology Physiological aspects Rodents Signal transduction STAT3 Transcription Factor - deficiency STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism T cells T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology Toxins Tumors
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