Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan

The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathione lyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic α-oxoaldehydes like methylglyoxal (MG). MG is formed as a by-product of glycolysis...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2010-12, Vol.2 (12), p.969-980
Hauptverfasser:	Scheckhuber, Christian Q, Mack, Sandra J, Strobel, Ingmar, Ricciardi, Filomena, Gispert, Suzana, Osiewacz, Heinz D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Fungal Genotype Glucose - metabolism Glutathione - metabolism Glycolysis Lactoylglutathione Lyase - genetics Lactoylglutathione Lyase - metabolism Molecular Sequence Data Mutation Phenotype Podospora - enzymology Podospora - genetics Podospora - growth & development Pyruvaldehyde - metabolism Research Paper Thiolester Hydrolases - genetics Thiolester Hydrolases - metabolism Time Factors Up-Regulation
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