Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

The ‘response to retention’ hypothesis of atherogenesis proposes that proteoglycans bind and retain low‐density lipoproteins (LDL) in the vessel wall. Platelet‐derived growth factor (PDGF) is strongly implicated in atherosclerosis and stimulates proteoglycan synthesis. Here we investigated the actio...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2010-06, Vol.14 (6b), p.1408-1418
Hauptverfasser:	Ballinger, Mandy L., Osman, Narin, Hashimura, Kazuhiko, Haan, Judy B. de, Jandeleit‐Dahm, Karin, Allen, Terri, Tannock, Lisa R., Rutledge, John C., Little, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aorta - drug effects Aorta - metabolism Apolipoprotein E Apolipoproteins E - deficiency Apolipoproteins E - metabolism Arteriosclerosis Atherogenesis Atherosclerosis Benzamides Biochemistry Biosynthesis Blood platelets Carotid artery Cholesterol Coronary artery disease Coronary vessels Dietary Fats - administration & dosage Dietary Fats - pharmacology Disaccharides Disaccharides - metabolism Dose-Response Relationship, Drug Glycosaminoglycans Glycosaminoglycans - metabolism Growth factors Heart Heart diseases Humans Imatinib Imatinib Mesylate Investigations Kinases Lipid Metabolism - drug effects Lipids Lipoproteins Lipoproteins, LDL - metabolism Low density lipoprotein Mice Molecular Weight Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Original Phosphorylation Phosphorylation - drug effects Piperazines - pharmacology Platelet-derived growth factor Protein Binding - drug effects Protein synthesis protein tyrosine kinase Proteoglycans Proteoglycans - biosynthesis Pyrimidines - pharmacology Receptors, Platelet-Derived Growth Factor - metabolism Smooth muscle Software Sulfur Sulfur - metabolism Triglycerides Tyrosine vascular smooth muscle
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