Specificity for human hemoglobin enhances Staphylococcus aureus infection
Iron is required for bacterial proliferation, and Staphylococcus aureus steals this metal from host hemoglobin during invasive infections. This process involves hemoglobin binding to the cell wall of S. aureus, heme extraction, passage through the cell envelope, and degradation to release free iron....
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| Veröffentlicht in: | Cell host & microbe 2010-12, Vol.8 (6), p.544-550 |
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| container_title | Cell host & microbe |
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| creator | Pishchany, Gleb McCoy, Amanda L Torres, Victor J Krause, Jens C Crowe, Jr, James E Fabry, Mary E Skaar, Eric P |
| description | Iron is required for bacterial proliferation, and Staphylococcus aureus steals this metal from host hemoglobin during invasive infections. This process involves hemoglobin binding to the cell wall of S. aureus, heme extraction, passage through the cell envelope, and degradation to release free iron. Herein, we demonstrate an enhanced ability of S. aureus to bind hemoglobin derived from humans as compared to other mammals. Increased specificity for human hemoglobin (hHb) translates into an improved ability to acquire iron and is entirely dependent on the staphylococcal hemoglobin receptor IsdB. This feature affects host-pathogen interaction as demonstrated by the increased susceptibility of hHb-expressing mice to systemic staphylococcal infection. Interestingly, enhanced utilization of human hemoglobin is not a uniform property of all bacterial pathogens. These results suggest a step in the evolution of S. aureus to better colonize the human host and establish hHb-expressing mice as a model of S. aureus pathogenesis. |
| doi_str_mv | 10.1016/j.chom.2010.11.002 |
| format | Article |
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This process involves hemoglobin binding to the cell wall of S. aureus, heme extraction, passage through the cell envelope, and degradation to release free iron. Herein, we demonstrate an enhanced ability of S. aureus to bind hemoglobin derived from humans as compared to other mammals. Increased specificity for human hemoglobin (hHb) translates into an improved ability to acquire iron and is entirely dependent on the staphylococcal hemoglobin receptor IsdB. This feature affects host-pathogen interaction as demonstrated by the increased susceptibility of hHb-expressing mice to systemic staphylococcal infection. Interestingly, enhanced utilization of human hemoglobin is not a uniform property of all bacterial pathogens. 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This process involves hemoglobin binding to the cell wall of S. aureus, heme extraction, passage through the cell envelope, and degradation to release free iron. Herein, we demonstrate an enhanced ability of S. aureus to bind hemoglobin derived from humans as compared to other mammals. Increased specificity for human hemoglobin (hHb) translates into an improved ability to acquire iron and is entirely dependent on the staphylococcal hemoglobin receptor IsdB. This feature affects host-pathogen interaction as demonstrated by the increased susceptibility of hHb-expressing mice to systemic staphylococcal infection. Interestingly, enhanced utilization of human hemoglobin is not a uniform property of all bacterial pathogens. These results suggest a step in the evolution of S. aureus to better colonize the human host and establish hHb-expressing mice as a model of S. aureus pathogenesis.</description><subject>Animals</subject><subject>Cation Transport Proteins - genetics</subject><subject>Cation Transport Proteins - metabolism</subject><subject>Hemoglobins - genetics</subject><subject>Hemoglobins - metabolism</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Iron - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mutation</subject><subject>Species Specificity</subject><subject>Staphylococcal Infections - blood</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus aureus - growth & development</subject><subject>Staphylococcus aureus - pathogenicity</subject><issn>1931-3128</issn><issn>1934-6069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBCIlsIPcEC5cUrwK7FzQUIVj0pIHApny3acxlVihzhB6t-T0FKB9jCr3dnZ1Q4A1wgmCKLsbpvoyjcJhlMBJRDiEzBHOaFxBrP89CdHMUGYz8BFCFsI0xQydA5mGCHKaMbnYLVujbal1bbfRaXvompopIsq0_hN7ZV1kXGVdNqEaN3LttrVXnuthxDJoTMjWFca3VvvLsFZKetgrg64AB9Pj-_Ll_j17Xm1fHiNNc1YH3Okp0g5JpTToiCSqSJNc6OQzihOpWTjkVByhAtmKGG4UJSWKseaK60UWYD7vW47qMYU2ri-k7VoO9vIbie8tOJ_x9lKbPyXIJBgiukocHsQ6PznYEIvGhu0qWvpjB-C4ON3csoYH5l4z9SdD6Ez5XELgmKyQGzFZIGYLBAIidGCcejm733Hkd-fk2-_goW9</recordid><startdate>20101216</startdate><enddate>20101216</enddate><creator>Pishchany, Gleb</creator><creator>McCoy, Amanda L</creator><creator>Torres, Victor J</creator><creator>Krause, Jens C</creator><creator>Crowe, Jr, James E</creator><creator>Fabry, Mary E</creator><creator>Skaar, Eric P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101216</creationdate><title>Specificity for human hemoglobin enhances Staphylococcus aureus infection</title><author>Pishchany, Gleb ; McCoy, Amanda L ; Torres, Victor J ; Krause, Jens C ; Crowe, Jr, James E ; Fabry, Mary E ; Skaar, Eric P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-81c1c1c5823484dd3a7bd559eb1c6425aa75070a812d7e4372db44fb92c8bcbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cation Transport Proteins - genetics</topic><topic>Cation Transport Proteins - metabolism</topic><topic>Hemoglobins - genetics</topic><topic>Hemoglobins - metabolism</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Iron - metabolism</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Mutation</topic><topic>Species Specificity</topic><topic>Staphylococcal Infections - blood</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcus aureus - growth & development</topic><topic>Staphylococcus aureus - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pishchany, Gleb</creatorcontrib><creatorcontrib>McCoy, Amanda L</creatorcontrib><creatorcontrib>Torres, Victor J</creatorcontrib><creatorcontrib>Krause, Jens C</creatorcontrib><creatorcontrib>Crowe, Jr, James E</creatorcontrib><creatorcontrib>Fabry, Mary E</creatorcontrib><creatorcontrib>Skaar, Eric P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell host & microbe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pishchany, Gleb</au><au>McCoy, Amanda L</au><au>Torres, Victor J</au><au>Krause, Jens C</au><au>Crowe, Jr, James E</au><au>Fabry, Mary E</au><au>Skaar, Eric P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specificity for human hemoglobin enhances Staphylococcus aureus infection</atitle><jtitle>Cell host & microbe</jtitle><addtitle>Cell Host Microbe</addtitle><date>2010-12-16</date><risdate>2010</risdate><volume>8</volume><issue>6</issue><spage>544</spage><epage>550</epage><pages>544-550</pages><issn>1931-3128</issn><eissn>1934-6069</eissn><abstract>Iron is required for bacterial proliferation, and Staphylococcus aureus steals this metal from host hemoglobin during invasive infections. 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| fulltext | fulltext |
| identifier | ISSN: 1931-3128 |
| ispartof | Cell host & microbe, 2010-12, Vol.8 (6), p.544-550 |
| issn | 1931-3128 1934-6069 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Hemoglobins - genetics Hemoglobins - metabolism Host-Pathogen Interactions Humans Iron - metabolism Mice Mice, Transgenic Mutation Species Specificity Staphylococcal Infections - blood Staphylococcal Infections - microbiology Staphylococcus aureus - growth & development Staphylococcus aureus - pathogenicity |
| title | Specificity for human hemoglobin enhances Staphylococcus aureus infection |
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