A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases

Several recent discoveries of the hallmark features of programmed cell death (PCD) in Plasmodium falciparum have presented the possibility of revealing novel targets for antimalarial therapy. Using a combination of cell-based assays, flow cytometry and fluorescence microscopy, we detected features i...

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Veröffentlicht in:	Cell death & disease 2010-02, Vol.1 (2), p.e26-e26
Hauptverfasser:	Ch'ng, J-H, Kotturi, S R, Chong, A G-L, Lear, M J, Tan, K S-W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/555 631/80/82/23 692/699/255/1629 Animals Antibodies Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Calcium - metabolism Cell Biology Cell Culture Chloroquine - pharmacology Cysteine Proteases - metabolism DNA - metabolism DNA Fragmentation - drug effects Dose-Response Relationship, Drug Fluorescent Dyes - metabolism Immunology Intracellular Space - drug effects Intracellular Space - metabolism Life Sciences Malaria - parasitology Mammals - metabolism Membrane Potential, Mitochondrial - drug effects Models, Biological Necrosis Original original-article Parasites - cytology Parasites - drug effects Parasites - enzymology Plasmodium falciparum Plasmodium falciparum - cytology Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Protozoan Proteins - metabolism Reproducibility of Results Signal Transduction - drug effects Staining and Labeling Time Factors
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