Principal-Component Analysis for Assessment of Population Stratification in Mitochondrial Medical Genetics

Although inherited mitochondrial genetic variation can cause human disease, no validated methods exist for control of confounding due to mitochondrial population stratification (PS). We sought to identify a reliable method for PS assessment in mitochondrial medical genetics. We analyzed mitochondria...

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Veröffentlicht in:	American journal of human genetics 2010-06, Vol.86 (6), p.904-917
Hauptverfasser:	Biffi, Alessandro, Anderson, Christopher D., Nalls, Michael A., Rahman, Rosanna, Sonni, Akshata, Cortellini, Lynelle, Rost, Natalia S., Matarin, Mar, Hernandez, Dena G., Plourde, Anna, de Bakker, Paul I.W., Ross, Owen A., Greenberg, Steven M., Furie, Karen L., Meschia, James F., Singleton, Andrew B., Saxena, Richa, Rosand, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA, Mitochondrial Europe - ethnology Fundamental and applied biological sciences. Psychology Gene Frequency General aspects. Genetic counseling Genes Genetic diversity Genetics of eukaryotes. Biological and molecular evolution Genetics, Population Genome-Wide Association Study Genomics Genotype Human Humans Medical genetics Medical sciences Mitochondria Molecular and cellular biology Pathology Polymorphism, Single Nucleotide Population genetics, reproduction patterns Population Groups - genetics Principal Component Analysis
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