Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection

Celiac disease (CD) is an intolerance to dietary proteins of wheat, barley, and rye. CD may have substantial morbidity, yet it is quite common with a prevalence of 1%–2% in Western populations. It is not clear why the CD phenotype is so prevalent despite its negative effects on human health, especia...

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Veröffentlicht in:	American journal of human genetics 2010-06, Vol.86 (6), p.970-977
Hauptverfasser:	Zhernakova, Alexandra, Elbers, Clara C., Ferwerda, Bart, Romanos, Jihane, Trynka, Gosia, Dubois, Patrick C., de Kovel, Carolien G.F., Franke, Lude, Oosting, Marije, Barisani, Donatella, Bardella, Maria Teresa, Joosten, Leo A.B., Saavalainen, Paivi, van Heel, David A., Catassi, Carlo, Netea, Mihai G., Wijmenga, Cisca
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Africa, Northern Bacteria Bacterial infections Bacterial Infections - genetics Barley Biological and medical sciences Celiac disease Celiac Disease - genetics Data processing Diets Disease Susceptibility Europe Evolution Evolution, Molecular Fundamental and applied biological sciences. Psychology Gene frequency General aspects. Genetic counseling Genetics Genetics of eukaryotes. Biological and molecular evolution Genetics, Population Genotype & phenotype Genotypes Gluten Haplotypes Hordeum vulgare Humans Infection Interleukin 1 Intolerance Intracellular Signaling Peptides and Proteins Lipopolysaccharides Medical genetics Medical sciences Molecular and cellular biology Morbidity muramyl dipeptide Natural selection NOD2 protein Nod2 Signaling Adaptor Protein - genetics Polymorphism, Single Nucleotide Population genetics Positive selection Proteins Proteins - genetics Selection, Genetic Triticum aestivum Wheat
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