Attenuated reovirus displays oncolysis with reduced host toxicity

Background: Although the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells. In immunocompromised hosts, however, wild-type reovirus can target healthy tissues, including heart,...

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Veröffentlicht in:	British journal of cancer 2011-01, Vol.104 (2), p.290-299
Hauptverfasser:	Kim, M, Garant, K A, zur Nieden, N I, Alain, T, Loken, S D, Urbanski, S J, Forsyth, P A, Rancourt, D E, Lee, P W K, Johnston, R N
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/596 692/699/255/2514 692/699/67/1059/602 Animals Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Cancer Research Cancer therapies Cell Line Chemotherapy Clinical trials DNA Primers Drug Resistance Embryo cells Epidemiology Fibrosarcoma Heart Humans Immune system Immunocompromised hosts Immunodeficiency Immunohistochemistry Infections Liver Lymphoma Medical research Medical sciences Mice Mice, SCID Microscopy, Electron Molecular Medicine Nonsense mutation Oncology Oncolysis Oncolytic Virotherapy Pancreas Pathogenesis Protein Biosynthesis Proteins Reoviridae - genetics Reoviridae - pathogenicity Reovirus Stem cells Tails Toxicity Transcription Transcription, Genetic Transformed cells Translation Translational Therapeutics Transplantation, Heterologous Tumors Virulence Viruses Western blotting Xenografts
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