Acrolein Inhalation Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production but Does Not Affect Acute Airways Neutrophilia

Acrolein is a reactive unsaturated aldehyde that is produced during endogenous oxidative processes and is a major bioactive component of environmental pollutants such as cigarette smoke. Because in vitro studies demonstrate that acrolein can inhibit neutrophil apoptosis, we evaluated the effects of...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-07, Vol.181 (1), p.736-745
Hauptverfasser:	Kasahara, David Itiro, Poynter, Matthew E, Othman, Ziryan, Hemenway, David, van der Vliet, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - administration & dosage Acrolein - pharmacology Acute Disease Administration, Inhalation Animals Apoptosis - drug effects Cytokines - biosynthesis Cytokines - immunology JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Lung Diseases - chemically induced Lung Diseases - immunology Lung Diseases - microbiology Male Mice Mice, Inbred C57BL Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology NF-kappa B - metabolism Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism
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