Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

Abstract Objective 25-Hydroxycholesterol (25HC) and its sulfated metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), regulate certain aspects of lipid metabolism in opposite ways. Hence, the enzyme for the biosynthesis of 25HC3S, oxysterol sulfotransferase (SULT2B1b), may play a crucial role in re...

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Veröffentlicht in:	Atherosclerosis 2011-02, Vol.214 (2), p.350-356
Hauptverfasser:	Bai, Qianming, Xu, Leyuan, Kakiyama, Genta, Runge-Morris, Melissa Ann, Hylemon, Phillip B, Yin, Lianhua, Pandak, William M, Ren, Shunlin
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxycholesterol (25HC) 25-Hydroxycholesterol-3-sulfate (25HC3S) agonists atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences biosynthesis Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiovascular Cells, Cultured Cholesterol Esters - metabolism Chromatography, High Pressure Liquid Cytosolic sulfotransferase (SULT2B1b) endothelial cells Endothelial Cells - drug effects Endothelial Cells - enzymology Fatty Acids, Nonesterified - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation gene overexpression genes high performance liquid chromatography homeostasis Humans Hydrocarbons, Fluorinated - pharmacology Hydroxycholesterols - metabolism Lipid metabolism lipids liver Liver X Receptors Medical sciences messenger RNA metabolites Orphan Nuclear Receptors - agonists Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism Oxysterol sulfation RNA, Messenger - metabolism signal transduction Signal Transduction - drug effects Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sulfonamides - pharmacology Sulfotransferases - genetics Sulfotransferases - metabolism Time Factors Transfection Triglycerides - metabolism Vertebrates: cardiovascular system
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