Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach
Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman a...
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| Veröffentlicht in: | Psychological science 2010-09, Vol.21 (9), p.1282-1290 |
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| creator | Derringer, Jaime Krueger, Robert F. Dick, Danielle M. Saccone, Scott Grucza, Richard A. Agrawal, Arpana Lin, Peng Almasy, Laura Edenberg, Howard J. Foroud, Tatiana Nurnberger, John I. Hesselbrock, Victor M. Kramer, John R. Kuperman, Samuel Porjesz, Bernice Schuckit, Marc A. Bierut, Laura J. |
| description | Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensationseeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between ¡ ndividuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior. |
| doi_str_mv | 10.1177/0956797610380699 |
| format | Article |
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The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensationseeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between ¡ ndividuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.</description><identifier>ISSN: 0956-7976</identifier><identifier>ISSN: 1467-9280</identifier><identifier>EISSN: 1467-9280</identifier><identifier>DOI: 10.1177/0956797610380699</identifier><identifier>PMID: 20732903</identifier><identifier>CODEN: PSYSET</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Behavior ; Behavior disorders ; Behavioral genetics ; Behavioural psychology ; Candidates ; Dopamine ; Dopamine - genetics ; Exploratory Behavior ; Female ; Genes ; Genetics ; Genome-Wide Association Study ; Genotype ; Human genetics ; Humans ; Male ; Medical genetics ; Middle Aged ; Modeling ; Neurobiology ; Neuropsychology ; Observational studies ; Personality ; Personality traits ; Phenotypic traits ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Psychological effects ; Psychological Tests ; Receptors ; Risk assessment ; Sensation - genetics ; Sensation seeking ; Statistical variance ; Studies ; Young Adult</subject><ispartof>Psychological science, 2010-09, Vol.21 (9), p.1282-1290</ispartof><rights>Copyright © 2010 Association for Psychological Science</rights><rights>The Author(s) 2010</rights><rights>Copyright SAGE PUBLICATIONS, INC. 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The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensationseeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between ¡ ndividuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.</description><subject>Adult</subject><subject>Aged</subject><subject>Behavior</subject><subject>Behavior disorders</subject><subject>Behavioral genetics</subject><subject>Behavioural psychology</subject><subject>Candidates</subject><subject>Dopamine</subject><subject>Dopamine - genetics</subject><subject>Exploratory Behavior</subject><subject>Female</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Human genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Middle Aged</subject><subject>Modeling</subject><subject>Neurobiology</subject><subject>Neuropsychology</subject><subject>Observational studies</subject><subject>Personality</subject><subject>Personality traits</subject><subject>Phenotypic traits</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychological effects</subject><subject>Psychological Tests</subject><subject>Receptors</subject><subject>Risk assessment</subject><subject>Sensation - genetics</subject><subject>Sensation seeking</subject><subject>Statistical variance</subject><subject>Studies</subject><subject>Young Adult</subject><issn>0956-7976</issn><issn>1467-9280</issn><issn>1467-9280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEUx4Modlu9e1EGPXgaffmdeBCW1VaholA9h0wms511JxmTWaH_fTNsXWqhNJcX8v287wtfHkIvMLzDWMr3oLmQWgoMVIHQ-hFaYCZkrYmCx2gxy_WsH6HjnDdQjqTiKToipRINdIG-_Ui-7d3Uh3V14UO2Ux9Dufnf88tpikP1KY526IOvznzw-UO1rFY2tH1rJ19fXOXJD9VyHFO07vIZetLZbfbPb-oJ-nX6-efqS33-_ezranleO6b4VAvWeSUbBY5T5TumHUDTNrwjijaMt63uqNUKFHCreQNSU8ccJU2nOkspoSfo49533DWDb50PU7JbM6Z-sOnKRNub_5XQX5p1_GsoUAxaFoO3NwYp_tn5PJmhz85vtzb4uMtGSSkAFKUPk1hQqTXRD5KScywxEbiQr--Qm7hLoSRWBlNOGOOsQG_ug7DGoAhhcv4e7CmXYs7Jd4cQMJh5R8zdHSktr26Hd2j4txQFqPdAtmt_a-r9hi_3_CZPMR38GAZBqFD0GjLEy0M</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Derringer, Jaime</creator><creator>Krueger, Robert F.</creator><creator>Dick, Danielle M.</creator><creator>Saccone, Scott</creator><creator>Grucza, Richard A.</creator><creator>Agrawal, Arpana</creator><creator>Lin, Peng</creator><creator>Almasy, Laura</creator><creator>Edenberg, Howard J.</creator><creator>Foroud, Tatiana</creator><creator>Nurnberger, John I.</creator><creator>Hesselbrock, Victor M.</creator><creator>Kramer, John R.</creator><creator>Kuperman, Samuel</creator><creator>Porjesz, Bernice</creator><creator>Schuckit, Marc A.</creator><creator>Bierut, Laura J.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach</title><author>Derringer, Jaime ; Krueger, Robert F. ; Dick, Danielle M. ; Saccone, Scott ; Grucza, Richard A. ; Agrawal, Arpana ; Lin, Peng ; Almasy, Laura ; Edenberg, Howard J. ; Foroud, Tatiana ; Nurnberger, John I. ; Hesselbrock, Victor M. ; Kramer, John R. ; Kuperman, Samuel ; Porjesz, Bernice ; Schuckit, Marc A. ; Bierut, Laura J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-64fe87b80c538ef49c00bdb5f283b45dd9f3a980805a95b0793c4c32bf8fa3323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Behavior</topic><topic>Behavior disorders</topic><topic>Behavioral genetics</topic><topic>Behavioural psychology</topic><topic>Candidates</topic><topic>Dopamine</topic><topic>Dopamine - genetics</topic><topic>Exploratory Behavior</topic><topic>Female</topic><topic>Genes</topic><topic>Genetics</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Human genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Middle Aged</topic><topic>Modeling</topic><topic>Neurobiology</topic><topic>Neuropsychology</topic><topic>Observational studies</topic><topic>Personality</topic><topic>Personality traits</topic><topic>Phenotypic traits</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychological effects</topic><topic>Psychological Tests</topic><topic>Receptors</topic><topic>Risk assessment</topic><topic>Sensation - genetics</topic><topic>Sensation seeking</topic><topic>Statistical variance</topic><topic>Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Derringer, Jaime</creatorcontrib><creatorcontrib>Krueger, Robert F.</creatorcontrib><creatorcontrib>Dick, Danielle M.</creatorcontrib><creatorcontrib>Saccone, Scott</creatorcontrib><creatorcontrib>Grucza, Richard A.</creatorcontrib><creatorcontrib>Agrawal, Arpana</creatorcontrib><creatorcontrib>Lin, Peng</creatorcontrib><creatorcontrib>Almasy, Laura</creatorcontrib><creatorcontrib>Edenberg, Howard J.</creatorcontrib><creatorcontrib>Foroud, Tatiana</creatorcontrib><creatorcontrib>Nurnberger, John I.</creatorcontrib><creatorcontrib>Hesselbrock, Victor M.</creatorcontrib><creatorcontrib>Kramer, John R.</creatorcontrib><creatorcontrib>Kuperman, Samuel</creatorcontrib><creatorcontrib>Porjesz, Bernice</creatorcontrib><creatorcontrib>Schuckit, Marc A.</creatorcontrib><creatorcontrib>Bierut, Laura J.</creatorcontrib><creatorcontrib>Gene Environment Association Studies (GENEVA) Consortium</creatorcontrib><creatorcontrib>Gene Environment Association Studies (GENEVA) Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychological science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Derringer, Jaime</au><au>Krueger, Robert F.</au><au>Dick, Danielle M.</au><au>Saccone, Scott</au><au>Grucza, Richard A.</au><au>Agrawal, Arpana</au><au>Lin, Peng</au><au>Almasy, Laura</au><au>Edenberg, Howard J.</au><au>Foroud, Tatiana</au><au>Nurnberger, John I.</au><au>Hesselbrock, Victor M.</au><au>Kramer, John R.</au><au>Kuperman, Samuel</au><au>Porjesz, Bernice</au><au>Schuckit, Marc A.</au><au>Bierut, Laura J.</au><aucorp>Gene Environment Association Studies (GENEVA) Consortium</aucorp><aucorp>Gene Environment Association Studies (GENEVA) Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach</atitle><jtitle>Psychological science</jtitle><addtitle>Psychol Sci</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>21</volume><issue>9</issue><spage>1282</spage><epage>1290</epage><pages>1282-1290</pages><issn>0956-7976</issn><issn>1467-9280</issn><eissn>1467-9280</eissn><coden>PSYSET</coden><abstract>Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensationseeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between ¡ ndividuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>20732903</pmid><doi>10.1177/0956797610380699</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Behavior Behavior disorders Behavioral genetics Behavioural psychology Candidates Dopamine Dopamine - genetics Exploratory Behavior Female Genes Genetics Genome-Wide Association Study Genotype Human genetics Humans Male Medical genetics Middle Aged Modeling Neurobiology Neuropsychology Observational studies Personality Personality traits Phenotypic traits Polymorphism Polymorphism, Single Nucleotide - genetics Psychological effects Psychological Tests Receptors Risk assessment Sensation - genetics Sensation seeking Statistical variance Studies Young Adult |
| title | Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach |
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