$Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone salvage therapy for recurrent or refractory childhood malignant lymphoma$

Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone salvage therapy for recurrent or refractory childhood malignant lymphoma

Children with recurrent or refractory malignant lymphoma generally have a poor prognosis. There is a need for new active drug combinations for this high-risk group of patients. This study evaluated the activity and toxicity of the methotrexate, ifosfamide, etoposide and dexamethasone (MIED) regimen...

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Veröffentlicht in:	Annals of oncology 2011-02, Vol.22 (2), p.468-471
Hauptverfasser:	Sandlund, J.T., Pui, C-H., Mahmoud, H., Zhou, Y., Lowe, E., Kaste, S., Kun, L.E., Krasin, M.J., Onciu, M., Behm, F.G., Ribeiro, R.C., Razzouk, B.I., Howard, S.C., Metzger, M.L., Hale, G.A., Rencher, R., Graham, K., Hudson, M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Child childhood Dexamethasone - administration & dosage Etoposide - administration & dosage Hematologic and hematopoietic diseases Hodgkin Disease - drug therapy Hodgkin Disease - pathology Humans Ifosfamide - administration & dosage Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lymphoma Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - pathology Medical sciences Methotrexate - administration & dosage Original Pharmacology. Drug treatments Recurrence recurrent refractory Salvage Therapy
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