Proteomic characterization of plasma-derived clotting factor VIII-von Willebrand factor concentrates

Proteomic methods were used to identify the levels of impurities in three commercial plasma‐derived clotting factor VIII‐von Willebrand factor (FVIII/VWF) concentrates. In all three concentrates, significant amounts of other plasma proteins were found. In Octanate and Haemoctin, two concentrates dev...

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Veröffentlicht in:	Electrophoresis 2009-10, Vol.30 (20), p.3636-3646
Hauptverfasser:	Clifton, James G., Huang, Feilei, Kovac, Spomenka, Yang, Xinli, Hixson, Douglas C., Josic, Djuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation Chromatography Clotting factor VIII Factor VIII - analysis Factor VIII - standards Fibrinogen - analysis Fibronectins - analysis Humans Proteomic analysis Proteomics - methods Prothrombin Tandem Mass Spectrometry von Willebrand factor von Willebrand Factor - analysis von Willebrand Factor - standards
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