Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization

Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation of angiogenesis and endothelial cell proliferation and migration. The goal of this study was to investigate whether 12-LOX plays a role in retinal neov...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2011-02, Vol.60 (2), p.614-624
Hauptverfasser: AL-SHABRAWEY, Mohamed, MUSSELL, Rene, SHEIBANI, Nader, RAO MADDIPATI, Krishna, KAHOOK, Khalid, TAWFIK, Amany, ELADL, Mohamed, SARTHY, Vijay, NUSSBAUM, Julian, EL-MARAKBY, Ahmed, SUN YOUNG PARK, GUREL, Zafer
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Sprache:eng
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