Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation

Recent advances in human islet transplantation are hampered by significant graft loss shortly after transplantation and inability to follow islet fate directly. Both issues were addressed by utilizing a dual-purpose therapy/imaging small interfering RNA (siRNA)-nanoparticle probe targeting apoptotic...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2011-02, Vol.60 (2), p.565-571
Hauptverfasser:	PING WANG, YIGIT, Mehmet V, MEDAROVA, Zdravka, LINGLING WEI, GUANGPING DAI, SCHUETZ, Christian, MOORE, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Blotting, Western Care and treatment Caspase 3 - metabolism Cell death Contrast agents Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene therapy Genetic aspects Genetic Therapy - methods Health aspects Humans Immunohistochemistry Immunology and Transplantation Insulin Insulin - metabolism Islets of Langerhans - metabolism Islets of Langerhans Transplantation - methods Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical sciences Mice Mice, Inbred NOD Nanoparticles Pancreatic beta cells Physiological aspects Protein expression Proteins Research design Reverse Transcriptase Polymerase Chain Reaction RNA interference RNA, Small Interfering Success Transplants & implants Type 1 diabetes
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