Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome
We describe cerebral salt wasting syndrome (CSWS) in a 5-year-old female child with Down syndrome who had acute myelopathy secondary to chronic atlantoaxial subluxation and fracture dislocation of the odontoid process. The patient developed hyponatraemia associated with excessive urine output and el...
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| Veröffentlicht in: | BMJ case reports 2009, Vol.2009 (feb19 1), p.bcr0620080135-bcr0620080135 |
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| container_issue | feb19 1 |
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| container_title | BMJ case reports |
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| creator | Abdel-Latif, Mohamed El-Amin Chan, Patrick W-K Goh, Adrian Yu-Teik Lum, Lucy Chai-See |
| description | We describe cerebral salt wasting syndrome (CSWS) in a 5-year-old female child with Down syndrome who had acute myelopathy secondary to chronic atlantoaxial subluxation and fracture dislocation of the odontoid process. The patient developed hyponatraemia associated with excessive urine output and elevated urine sodium concentration following her injury. An administered volume-for-volume replacement of urine loss with 0.9% sodium chloride resulted in an excellent outcome. This patient illustrates the importance of ascertaining CSWS in children with spinal cord disorders, in addition to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and diabetes insipidus (DI) commonly encountered following a central nervous system (CNS) injury, as the specific treatment approaches is clearly associated with an excellent outcome. |
| doi_str_mv | 10.1136/bcr.06.2008.0135 |
| format | Article |
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The patient developed hyponatraemia associated with excessive urine output and elevated urine sodium concentration following her injury. An administered volume-for-volume replacement of urine loss with 0.9% sodium chloride resulted in an excellent outcome. This patient illustrates the importance of ascertaining CSWS in children with spinal cord disorders, in addition to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and diabetes insipidus (DI) commonly encountered following a central nervous system (CNS) injury, as the specific treatment approaches is clearly associated with an excellent outcome.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr.06.2008.0135</identifier><identifier>PMID: 21686919</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Asia ; Chinese ; Chloride ; Down syndrome ; Female ; Fractures ; Head injuries ; Hyponatremia ; Nervous system ; Plasma ; Salt ; Sodium ; Trauma ; Unusual Association of Diseases/Symptoms ; Urine</subject><ispartof>BMJ case reports, 2009, Vol.2009 (feb19 1), p.bcr0620080135-bcr0620080135</ispartof><rights>2009 BMJ Publishing Group Ltd</rights><rights>Copyright: 2009 2009 BMJ Publishing Group Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3045-1dcc7ea0429e8a8ecb3bb171e181263314ca78340ba1905f45ef954d3b7ab4793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027581/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027581/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4022,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21686919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Latif, Mohamed El-Amin</creatorcontrib><creatorcontrib>Chan, Patrick W-K</creatorcontrib><creatorcontrib>Goh, Adrian Yu-Teik</creatorcontrib><creatorcontrib>Lum, Lucy Chai-See</creatorcontrib><title>Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>We describe cerebral salt wasting syndrome (CSWS) in a 5-year-old female child with Down syndrome who had acute myelopathy secondary to chronic atlantoaxial subluxation and fracture dislocation of the odontoid process. The patient developed hyponatraemia associated with excessive urine output and elevated urine sodium concentration following her injury. An administered volume-for-volume replacement of urine loss with 0.9% sodium chloride resulted in an excellent outcome. This patient illustrates the importance of ascertaining CSWS in children with spinal cord disorders, in addition to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and diabetes insipidus (DI) commonly encountered following a central nervous system (CNS) injury, as the specific treatment approaches is clearly associated with an excellent outcome.</description><subject>Asia</subject><subject>Chinese</subject><subject>Chloride</subject><subject>Down syndrome</subject><subject>Female</subject><subject>Fractures</subject><subject>Head injuries</subject><subject>Hyponatremia</subject><subject>Nervous system</subject><subject>Plasma</subject><subject>Salt</subject><subject>Sodium</subject><subject>Trauma</subject><subject>Unusual Association of Diseases/Symptoms</subject><subject>Urine</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc9rHCEcxaUkNGGz957KQA85lN36VWd0LoGwzS8I9NJCoQdRx0ldZjTVmWzy38dhk2XTS7wo-nnP7-Mh9AnwEoBW37SJS1wtCcZiiYGWH9Ax8JIveI1_H-ydj9A8pTXOiwITjH5ERwQqUdVQH6M_KxutjqorkuqGYqPS4PxdkZ58E0NvizZ0XdhMV2rolB-CenQZbqMywxht0bjUBaMGF3zhfPE9bPxOfIIOW9UlO3_ZZ-jX5cXP1fXi9sfVzer8dqEpZuUCGmO4VZiR2golrNFUa-BgQQCpaB7aKC4ow1pBjcuWlbatS9ZQzZVmvKYzdLb1vR91bxtj_ZADyfvoehWfZFBOvn3x7q-8Cw-SYsJLAdng9MUghn-jTYPsXTK2y4FtGJMUnALBhE5fffmPXIcx-pxOAhekZoQxkim8pUwMKUXb7mYBLKfuZO5O4kpO3cmpuyz5vJ9hJ3htKgNft4Du1-_bPQMCGKRb</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Abdel-Latif, Mohamed El-Amin</creator><creator>Chan, Patrick W-K</creator><creator>Goh, Adrian Yu-Teik</creator><creator>Lum, Lucy Chai-See</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2009</creationdate><title>Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome</title><author>Abdel-Latif, Mohamed El-Amin ; Chan, Patrick W-K ; Goh, Adrian Yu-Teik ; Lum, Lucy Chai-See</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3045-1dcc7ea0429e8a8ecb3bb171e181263314ca78340ba1905f45ef954d3b7ab4793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Asia</topic><topic>Chinese</topic><topic>Chloride</topic><topic>Down syndrome</topic><topic>Female</topic><topic>Fractures</topic><topic>Head injuries</topic><topic>Hyponatremia</topic><topic>Nervous system</topic><topic>Plasma</topic><topic>Salt</topic><topic>Sodium</topic><topic>Trauma</topic><topic>Unusual Association of Diseases/Symptoms</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Latif, Mohamed El-Amin</creatorcontrib><creatorcontrib>Chan, Patrick W-K</creatorcontrib><creatorcontrib>Goh, Adrian Yu-Teik</creatorcontrib><creatorcontrib>Lum, Lucy Chai-See</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Latif, Mohamed El-Amin</au><au>Chan, Patrick W-K</au><au>Goh, Adrian Yu-Teik</au><au>Lum, Lucy Chai-See</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2009</date><risdate>2009</risdate><volume>2009</volume><issue>feb19 1</issue><spage>bcr0620080135</spage><epage>bcr0620080135</epage><pages>bcr0620080135-bcr0620080135</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>We describe cerebral salt wasting syndrome (CSWS) in a 5-year-old female child with Down syndrome who had acute myelopathy secondary to chronic atlantoaxial subluxation and fracture dislocation of the odontoid process. The patient developed hyponatraemia associated with excessive urine output and elevated urine sodium concentration following her injury. An administered volume-for-volume replacement of urine loss with 0.9% sodium chloride resulted in an excellent outcome. This patient illustrates the importance of ascertaining CSWS in children with spinal cord disorders, in addition to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and diabetes insipidus (DI) commonly encountered following a central nervous system (CNS) injury, as the specific treatment approaches is clearly associated with an excellent outcome.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>21686919</pmid><doi>10.1136/bcr.06.2008.0135</doi><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Asia Chinese Chloride Down syndrome Female Fractures Head injuries Hyponatremia Nervous system Plasma Salt Sodium Trauma Unusual Association of Diseases/Symptoms Urine |
| title | Cerebral salt wasting syndrome following atlantoaxial fracture dislocation in Down syndrome |
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