Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?
Two patients with giant, 8 cm and 19 cm melanomas of the upper extremity, respectively, are presented and discussed. Both patients had neglected their tumours and sought medical attention only after the appearance of distressing symptoms (for example, bleeding). Palpable lymph nodes were found on ph...
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| Veröffentlicht in: | BMJ case reports 2009, Vol.2009 (oct05 1), p.bcr0720092073-bcr0720092073 |
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| container_issue | oct05 1 |
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| container_title | BMJ case reports |
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| creator | Tseng, William W Doyle, Judy A Maguiness, Sheilagh Horvai, Andrew E Kashani-Sabet, Mohammed Leong, Stanley P L |
| description | Two patients with giant, 8 cm and 19 cm melanomas of the upper extremity, respectively, are presented and discussed. Both patients had neglected their tumours and sought medical attention only after the appearance of distressing symptoms (for example, bleeding). Palpable lymph nodes were found on physical examination but no evidence of distant metastases was noted on imaging studies despite such enormous primary tumours. Both patients underwent aggressive treatment, including complete surgical resection of the primary tumour and ipsilateral axillary lymph node dissection. One patient had no evidence of local recurrence, but developed metastatic disease at 6 months follow-up. The other patient developed local recurrence and distant metastases within 2 months of resection. |
| doi_str_mv | 10.1136/bcr.07.2009.2073 |
| format | Article |
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Both patients had neglected their tumours and sought medical attention only after the appearance of distressing symptoms (for example, bleeding). Palpable lymph nodes were found on physical examination but no evidence of distant metastases was noted on imaging studies despite such enormous primary tumours. Both patients underwent aggressive treatment, including complete surgical resection of the primary tumour and ipsilateral axillary lymph node dissection. One patient had no evidence of local recurrence, but developed metastatic disease at 6 months follow-up. The other patient developed local recurrence and distant metastases within 2 months of resection.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr.07.2009.2073</identifier><identifier>PMID: 21977058</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>80 Years ; Biopsy ; Dissection ; Lymphatic system ; Male ; Medical imaging ; Medical prognosis ; Melanoma ; Metastasis ; NMR ; Nuclear magnetic resonance ; Patients ; Plastic surgery ; Skin & tissue grafts ; Tomography ; Tumors ; Unusual Presentation of More Common Disease/Injury ; USA/Canada ; White</subject><ispartof>BMJ case reports, 2009, Vol.2009 (oct05 1), p.bcr0720092073-bcr0720092073</ispartof><rights>2009 BMJ Publishing Group Ltd</rights><rights>Copyright: 2009 2009 BMJ Publishing Group Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3743-62f0b3c314f8fd2f8ca94bd69754153e33a57348ca817621b7da15cd6940900b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027359/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027359/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4023,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21977058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tseng, William W</creatorcontrib><creatorcontrib>Doyle, Judy A</creatorcontrib><creatorcontrib>Maguiness, Sheilagh</creatorcontrib><creatorcontrib>Horvai, Andrew E</creatorcontrib><creatorcontrib>Kashani-Sabet, Mohammed</creatorcontrib><creatorcontrib>Leong, Stanley P L</creatorcontrib><title>Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Two patients with giant, 8 cm and 19 cm melanomas of the upper extremity, respectively, are presented and discussed. 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The other patient developed local recurrence and distant metastases within 2 months of resection.</description><subject>80 Years</subject><subject>Biopsy</subject><subject>Dissection</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Plastic surgery</subject><subject>Skin & tissue grafts</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Unusual Presentation of More Common Disease/Injury</subject><subject>USA/Canada</subject><subject>White</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1rHCEYxiWkJMs2956C0EMOZbd-zIzaQ0II-SgEemmhh4I4jpO6zOhWnYX8932X3YQkl3hQef09D-_rg9AnSpaU8uZra9OSiCUjRMEm-AGaUVGLhVDk9-GL-zE6yXlFYHFayYofoWNGlRCkljP059abULCdigkuThmPbjAhjiZ_w27jOxesw31MeJ38aNIjLtMYp4R96CbrOtzFNJpgH6EA0mJyMcVbnH1x-eIj-tCbIbuT_TlHv26uf17dLe5_3H6_urxftFxUfNGwnrTcQne97DvWS2tU1XaNEnVFa-44N7XgFZQlFQ2jregMrS0AFVEEpHN0vvNdT-3oOutCSWbQ-5Z1NF6_fgn-r36IG80JE7xWYHC2N0jx3-Ry0aPP1g3D7lO0VI0EsiFAfn5DruA7AkynqZBMVUyyGiiyo2yKOSfXP_dCid6GpyE8TYTehqe34YHk9OUMz4KnqAD4sgPacfW-3X9bI6PR</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Tseng, William W</creator><creator>Doyle, Judy A</creator><creator>Maguiness, Sheilagh</creator><creator>Horvai, Andrew E</creator><creator>Kashani-Sabet, Mohammed</creator><creator>Leong, Stanley P L</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2009</creationdate><title>Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites?</title><author>Tseng, William W ; 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Both patients had neglected their tumours and sought medical attention only after the appearance of distressing symptoms (for example, bleeding). Palpable lymph nodes were found on physical examination but no evidence of distant metastases was noted on imaging studies despite such enormous primary tumours. Both patients underwent aggressive treatment, including complete surgical resection of the primary tumour and ipsilateral axillary lymph node dissection. One patient had no evidence of local recurrence, but developed metastatic disease at 6 months follow-up. The other patient developed local recurrence and distant metastases within 2 months of resection.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>21977058</pmid><doi>10.1136/bcr.07.2009.2073</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 80 Years Biopsy Dissection Lymphatic system Male Medical imaging Medical prognosis Melanoma Metastasis NMR Nuclear magnetic resonance Patients Plastic surgery Skin & tissue grafts Tomography Tumors Unusual Presentation of More Common Disease/Injury USA/Canada White |
| title | Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites? |
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