Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis
AIM： To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis （B. lactis） in an adoptive transfer model of colitis. METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to t...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2011-01, Vol.17 (4), p.459-469 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Philippe, David Favre, Laurent Foata, Francis Adolfsson, Oskar Perruisseau-Carrier, Genevieve Vidal, Karine Reuteler, Gloria Dayer-Schneider, Johanna Mueller, Christoph Blum, Stéphanie |
| description | AIM： To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis （B. lactis） in an adoptive transfer model of colitis. METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS： All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION： Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. |
| doi_str_mv | 10.3748/wjg.v17.i4.459 |
| format | Article |
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METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS： All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION： Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v17.i4.459</identifier><identifier>PMID: 21274375</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Adoptive Transfer ; Animals ; Bifidobacterium - immunology ; Biomarkers - metabolism ; Body Weight ; Colitis - immunology ; Colitis - microbiology ; Colitis - pathology ; Disease Models, Animal ; Feces - microbiology ; Humans ; Inflammation - drug therapy ; Inflammation - immunology ; Inflammation - microbiology ; Mice ; Mice, Inbred C57BL ; Original ; Probiotics - administration & dosage ; Probiotics - therapeutic use ; T-Lymphocytes - immunology ; 双歧杆菌 ; 发病 ; 小鼠 ; 模型 ; 炎症介质 ; 球菌 ; 结肠炎 ; 调节性T细胞</subject><ispartof>World journal of gastroenterology : WJG, 2011-01, Vol.17 (4), p.459-469</ispartof><rights>2011 Baishideng Publishing Group Co., Limited. All rights reserved. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-36d57acb763f572570bc9efa4d017708ce6dd9a8baed9127f660ffaa23b900993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027012/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027012/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21274375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Philippe, David</creatorcontrib><creatorcontrib>Favre, Laurent</creatorcontrib><creatorcontrib>Foata, Francis</creatorcontrib><creatorcontrib>Adolfsson, Oskar</creatorcontrib><creatorcontrib>Perruisseau-Carrier, Genevieve</creatorcontrib><creatorcontrib>Vidal, Karine</creatorcontrib><creatorcontrib>Reuteler, Gloria</creatorcontrib><creatorcontrib>Dayer-Schneider, Johanna</creatorcontrib><creatorcontrib>Mueller, Christoph</creatorcontrib><creatorcontrib>Blum, Stéphanie</creatorcontrib><title>Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis （B. lactis） in an adoptive transfer model of colitis. METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS： All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION： Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.</description><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>Bifidobacterium - immunology</subject><subject>Biomarkers - metabolism</subject><subject>Body Weight</subject><subject>Colitis - immunology</subject><subject>Colitis - microbiology</subject><subject>Colitis - pathology</subject><subject>Disease Models, Animal</subject><subject>Feces - microbiology</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Inflammation - microbiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Original</subject><subject>Probiotics - administration & dosage</subject><subject>Probiotics - therapeutic use</subject><subject>T-Lymphocytes - immunology</subject><subject>双歧杆菌</subject><subject>发病</subject><subject>小鼠</subject><subject>模型</subject><subject>炎症介质</subject><subject>球菌</subject><subject>结肠炎</subject><subject>调节性T细胞</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9P3TAMx6MJNN7YrjtO5bRTS360dXKZxNA2kJC4wDly0-QR1CbQpEz89wvi7QlOtuWPv7b8JeQro42AVp7-vd82Twwa3zZtpz6QDedM1Vy29IBsGKVQK8HhiHxK6Z5SLkTHP5Ijzji0AroNufnpnR_jgCbbxa9zNZXMpwpztmHFbFMVQ7K5iq7ywU04z5h9DKWosJrXxQdbzXG00wth4uTL9Gdy6HBK9ssuHpPb379uzi_qq-s_l-dnV7Upu3Mt-rEDNAP0wnXAO6CDUdZhO1IGQKWx_TgqlAPaUZWLXd9T5xC5GBSlSolj8uNV92EdZjsaG_KCk35Y_IzLs47o9ftO8Hd6G5-0oBwo40Xg-05giY-rTVnPPhk7TRhsXJOWrRRMSWCFbF5Js8SUFuv2WxjVL07o4oQuTmjf6uJEGfj29rY9_v_1BTjZKd7FsH30YbtnBABIkFT8A-jqk2Q</recordid><startdate>20110128</startdate><enddate>20110128</enddate><creator>Philippe, David</creator><creator>Favre, Laurent</creator><creator>Foata, Francis</creator><creator>Adolfsson, Oskar</creator><creator>Perruisseau-Carrier, Genevieve</creator><creator>Vidal, Karine</creator><creator>Reuteler, Gloria</creator><creator>Dayer-Schneider, Johanna</creator><creator>Mueller, Christoph</creator><creator>Blum, Stéphanie</creator><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110128</creationdate><title>Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis</title><author>Philippe, David ; Favre, Laurent ; Foata, Francis ; Adolfsson, Oskar ; Perruisseau-Carrier, Genevieve ; Vidal, Karine ; Reuteler, Gloria ; Dayer-Schneider, Johanna ; Mueller, Christoph ; Blum, Stéphanie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-36d57acb763f572570bc9efa4d017708ce6dd9a8baed9127f660ffaa23b900993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adoptive Transfer</topic><topic>Animals</topic><topic>Bifidobacterium - immunology</topic><topic>Biomarkers - metabolism</topic><topic>Body Weight</topic><topic>Colitis - immunology</topic><topic>Colitis - microbiology</topic><topic>Colitis - pathology</topic><topic>Disease Models, Animal</topic><topic>Feces - microbiology</topic><topic>Humans</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - immunology</topic><topic>Inflammation - microbiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Original</topic><topic>Probiotics - administration & dosage</topic><topic>Probiotics - therapeutic use</topic><topic>T-Lymphocytes - immunology</topic><topic>双歧杆菌</topic><topic>发病</topic><topic>小鼠</topic><topic>模型</topic><topic>炎症介质</topic><topic>球菌</topic><topic>结肠炎</topic><topic>调节性T细胞</topic><toplevel>online_resources</toplevel><creatorcontrib>Philippe, David</creatorcontrib><creatorcontrib>Favre, Laurent</creatorcontrib><creatorcontrib>Foata, Francis</creatorcontrib><creatorcontrib>Adolfsson, Oskar</creatorcontrib><creatorcontrib>Perruisseau-Carrier, Genevieve</creatorcontrib><creatorcontrib>Vidal, Karine</creatorcontrib><creatorcontrib>Reuteler, Gloria</creatorcontrib><creatorcontrib>Dayer-Schneider, Johanna</creatorcontrib><creatorcontrib>Mueller, Christoph</creatorcontrib><creatorcontrib>Blum, Stéphanie</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Philippe, David</au><au>Favre, Laurent</au><au>Foata, Francis</au><au>Adolfsson, Oskar</au><au>Perruisseau-Carrier, Genevieve</au><au>Vidal, Karine</au><au>Reuteler, Gloria</au><au>Dayer-Schneider, Johanna</au><au>Mueller, Christoph</au><au>Blum, Stéphanie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2011-01-28</date><risdate>2011</risdate><volume>17</volume><issue>4</issue><spage>459</spage><epage>469</epage><pages>459-469</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis （B. lactis） in an adoptive transfer model of colitis. METHODS： Donor and recipient mice received either B. lactis or bacterial culture medium as control （deMan Rogosa Sharpe） in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS： All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION： Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Co., Limited</pub><pmid>21274375</pmid><doi>10.3748/wjg.v17.i4.459</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2011-01, Vol.17 (4), p.459-469 |
| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adoptive Transfer Animals Bifidobacterium - immunology Biomarkers - metabolism Body Weight Colitis - immunology Colitis - microbiology Colitis - pathology Disease Models, Animal Feces - microbiology Humans Inflammation - drug therapy Inflammation - immunology Inflammation - microbiology Mice Mice, Inbred C57BL Original Probiotics - administration & dosage Probiotics - therapeutic use T-Lymphocytes - immunology 双歧杆菌 发病 小鼠 模型 炎症介质 球菌 结肠炎 调节性T细胞 |
| title | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis |
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