Glycogen Storage Disease Type Ia in Canines : A Model for Human Metabolic and Genetic Liver Disease

A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-α. Metabolic, clinicopathologic, pathologic, and clinical manifestations of GSDIa observed in this model...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioMed research international 2011-01, Vol.2011 (2011), p.1-9
Hauptverfasser:	Erger, Kirsten, Fiske, Laurie, Specht, Andrew J., Cossette, Travis, Verstegen, John, Campbell-Thompson, Martha, Struck, Maggie B., Lee, Young Mok, Chou, Janice Y., Byrne, Barry J., Correia, Catherine E., Mah, Cathryn S., Weinstein, David A., Conlon, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Clinical Trials as Topic Disease Models, Animal Dog Diseases - genetics Dog Diseases - metabolism Dogs Gene mutations Genetic aspects Glycogen Storage Disease Type I - diagnosis Glycogen Storage Disease Type I - genetics Glycogen Storage Disease Type I - metabolism Glycogen Storage Disease Type I - pathology Glycogen Storage Disease Type I - veterinary Glycogenosis Humans Liver Diseases - genetics Liver Diseases - metabolism Liver Diseases - veterinary Metabolic disorders Mortality Mutation Pathology Proteins Review Risk factors Stem cells Veterinary medicine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!