The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias

Acute leukemia is the most common type of childhood and adolescence cancer, characterized by clonal proliferation of variably differentiated myeloid or lymphoid precursors. Recent insights into the molecular pathogenesis of leukemia have shown that epigenetic modifications, such as deacetylation of...

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Veröffentlicht in:	BioMed research international 2011-01, Vol.2011 (2011), p.1-9
Hauptverfasser:	Pession, Andrea, Biagi, Carlotta, Serravalle, Salvatore, Masetti, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Antimitotic agents Antineoplastic agents Apoptosis Cancer Chemotherapy Child Clinical Trials as Topic Cyclin-dependent kinases DNA DNA methylation Drug Evaluation, Preclinical Drug therapy Epigenetics Health aspects Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - therapeutic use Histone Deacetylases - metabolism Humans Leukemia Leukemia - drug therapy Leukemia - enzymology Methylation Physiological aspects Review Risk assessment Rodents Studies Tumors
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