Phosphoinositides are essential co-activators for p21-activated kinase 1 (Pak1)
Phospholipid-enriched membranes such as the plasma membrane can serve as direct regulators of kinase signaling. Pak1 is involved in growth factor signaling at the plasma membrane and its dysregulation is implicated in cancer. Pak1 adopts an autoinhibited conformation that is relieved upon binding to...
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| Veröffentlicht in: | Molecular cell 2010-11, Vol.40 (3), p.493-500 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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