Genetic and epigenetic control of the efficiency and fidelity of cross‐species prion transmission

Summary Self‐perpetuating amyloid‐based protein isoforms (prions) transmit neurodegenerative diseases in mammals and phenotypic traits in yeast. Although mechanisms that control species specificity of prion transmission are poorly understood, studies of closely related orthologues of yeast prion pro...

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Veröffentlicht in:	Molecular microbiology 2010-06, Vol.76 (6), p.1483-1499
Hauptverfasser:	Chen, Buxin, Bruce, Kathryn L., Newnam, Gary P., Gyoneva, Stefka, Romanyuk, Andrey V., Chernoff, Yury O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Amyloid - metabolism Bacteria Bacterial proteins Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Epigenetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Gene Transfer, Horizontal Genotype & phenotype Mammals Medical sciences Microbiology Molecular Sequence Data Neurology Non conventional transmissible agents Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Polymorphism, Genetic Prions Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment
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