Molecular Basis for the Differences in Lipid and Lipoprotein Binding Properties of Human Apolipoproteins E3 and E4

Human apolipoprotein (apo) E4 binds preferentially to very low-density lipoproteins (VLDLs), whereas apoE3 binds preferentially to high-density lipoproteins (HDLs), resulting in different plasma cholesterol levels for the two isoforms. To understand the molecular basis for this effect, we engineered...

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Veröffentlicht in:	Biochemistry (Easton) 2010-12, Vol.49 (51), p.10881-10889
Hauptverfasser:	Nguyen, David, Dhanasekaran, Padmaja, Nickel, Margaret, Nakatani, Ryosuke, Saito, Hiroyuki, Phillips, Michael C, Lund-Katz, Sissel
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoprotein E3 - chemistry Apolipoprotein E3 - genetics Apolipoprotein E3 - metabolism Apolipoprotein E4 - chemistry Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Escherichia coli - genetics Gene Expression Humans Lipid Metabolism Lipoproteins - metabolism Lipoproteins, HDL - metabolism Lipoproteins, VLDL - metabolism Mutation Protein Binding Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Structure, Tertiary
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