Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages

OBJECTIVE—Telomerase serves as a critical regulator of tissue renewal. Although telomerase activity is inducible in response to various environmental cues, it remains unknown whether telomerase is activated during the inflammatory remodeling underlying atherosclerosis formation. To address this ques...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-02, Vol.31 (2), p.245-252
Hauptverfasser:	Gizard, Florence, Heywood, Elizabeth B, Findeisen, Hannes M, Zhao, Yue, Jones, Karrie L, Cudejko, Céline, Post, Ginell R, Staels, Bart, Bruemmer, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Associated diseases and complications Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Coronary Vessels - metabolism Coronary Vessels - pathology Coronary Vessels - physiopathology Diabetes. Impaired glucose tolerance Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Humans Inflammation - metabolism Inflammation - pathology Inflammation - physiopathology Lipopolysaccharides - pharmacology Lipoproteins, LDL - pharmacology Macrophages - drug effects Macrophages - enzymology Macrophages - pathology Medical sciences Mice Mice, Knockout NF-kappa B - metabolism Receptors, LDL - deficiency Receptors, LDL - genetics Telomerase - genetics Telomerase - metabolism Tumor Necrosis Factor-alpha - pharmacology
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