Sts1 Plays a Key Role in Targeting Proteasomes to the Nucleus

The evidence that nuclear proteins can be degraded by cytosolic proteasomes has received considerable experimental support. However, the presence of proteasome subunits in the nucleus also suggests that protein degradation could occur within this organelle. We determined that Sts1 can target proteas...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (4), p.3104-3118
Hauptverfasser:	Chen, Li, Romero, Lizbeth, Chuang, Show-Mei, Tournier, Vincent, Joshi, Kishore Kumar, Lee, Jung Ah, Kovvali, Gopala, Madura, Kiran
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Cell Nucleus - genetics Cell Nucleus - metabolism Nuclear Localization Signal Nuclear Localization Signals - genetics Nuclear Localization Signals - metabolism Nuclear Translocation Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Degradation Protein Synthesis and Degradation Protein-Protein Interactions Proteolytic Enzymes Rad23 Rpn10 Rpn11 Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Srp1 Ubiquitin
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