Structural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus Release

BST-2/tetherin is a host antiviral molecule that functions to potently inhibit the release of enveloped viruses from infected cells. In return, viruses have evolved antagonists to this activity. BST-2 traps budding virions by using two separate membrane-anchoring regions that simultaneously incorpor...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (4), p.2987-2997
Hauptverfasser:	Swiecki, Melissa, Scheaffer, Suzanne M., Allaire, Marc, Fremont, Daved H., Colonna, Marco, Brett, Tom J.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - metabolism CRYSTAL STRUCTURE Crystallography, X-Ray DESIGN DIMERS DISULFIDES Evolution, Molecular GPI-Linked Proteins - chemistry GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism HEK293 Cells Host Antiviral Response Humans Immunology Innate Immunity Interferon Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism MEMBRANES Mice national synchrotron light source ORIGIN PLASTICITY PROGENY Protein Stability Protein Structure, Secondary Protein Structure, Tertiary SCATTERING STABILITY STRUCTURAL CHEMICAL ANALYSIS Viral Replication Virus Release - physiology VIRUSES Viruses - metabolism X-ray Crystallography X-ray Scattering
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