Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-termi...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (4), p.2675-2680
Hauptverfasser:	Hellman, Maarit, Arumäe, Urmas, Yu, Li-ying, Lindholm, Päivi, Peränen, Johan, Saarma, Mart, Permi, Perttu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - genetics Antigens, Nuclear - metabolism Apoptosis Bax bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Cells, Cultured Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Ku Autoantigen Ku70 Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Neurodegeneration Neurons - metabolism Neurotrophic Factor NMR Nuclear Magnetic Resonance, Biomolecular Oxidopamine - adverse effects Oxidopamine - pharmacology Parkinson Disease Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - genetics Parkinson Disease, Secondary - metabolism Protein Structure and Folding Protein Structure, Tertiary Proteins - genetics Proteins - metabolism Rats Structural Homology, Protein Sympatholytics - adverse effects Sympatholytics - pharmacokinetics
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