Recombinant factor XIII diminishes multiple organ dysfunction in rats caused by gut ischemia-reperfusion injury

Plasma factor XIII (FXIII) is responsible for stabilization of fibrin clot at the final stage of blood coagulation. Because FXIII has also been shown to modulate inflammation and endothelial permeability, we hypothesized that FXIII diminishes multiple organ dysfunction caused by gut I/R injury. A mo...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2009-06, Vol.31 (6), p.621-627
Hauptverfasser:	Zaets, Sergey B, Xu, Da-Zhong, Lu, Qi, Feketova, Eleonora, Berezina, Tamara L, Gruda, Maryann, Malinina, Inga V, Deitch, Edwin A, Olsen, Eva H N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane Permeability - drug effects Enzyme Activation - drug effects Factor XIII - pharmacology Gastrointestinal Tract - metabolism Gastrointestinal Tract - pathology Humans Lung - drug effects Lung - metabolism Male Mesenteric Artery, Superior Microcirculation - drug effects Multiple Organ Failure - drug therapy Multiple Organ Failure - etiology Neutrophils - metabolism Peroxidase - metabolism Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Regional Blood Flow - drug effects Reperfusion Injury - physiopathology Respiratory Burst - drug effects
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