Bioengineered Dental Tissues Grown in the Rat Jaw
Our long-term objective is to develop methods to form, in the jaw, bioengineered replacement teeth that exhibit physical properties and functions similar to those of natural teeth. Our results show that cultured rat tooth bud cells, seeded onto biodegradable scaffolds, implanted into the jaws of adu...
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| Veröffentlicht in: | Journal of dental research 2008-08, Vol.87 (8), p.745-750 |
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| container_title | Journal of dental research |
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| creator | Duailibi, S.E. Duailibi, M.T. Zhang, W. Asrican, R. Vacanti, J.P. Yelick, P.C. |
| description | Our long-term objective is to develop methods to form, in the jaw, bioengineered replacement teeth that exhibit physical properties and functions similar to those of natural teeth. Our results show that cultured rat tooth bud cells, seeded onto biodegradable scaffolds, implanted into the jaws of adult rat hosts and grown for 12 weeks, formed small, organized, bioengineered tooth crowns, containing dentin, enamel, pulp, and periodontal ligament tissues, similar to identical cell-seeded scaffolds implanted and grown in the omentum. Radiographic, histological, and immunohistochemical analyses showed that bioengineered teeth consisted of organized dentin, enamel, and pulp tissues. This study advances practical applications for dental tissue engineering by demonstrating that bioengineered tooth tissues can be regenerated at the site of previously lost teeth, and supports the use of tissue engineering strategies in humans, to regenerate previously lost and/or missing teeth. The results presented in this report support the feasibility of bioengineered replacement tooth formation in the jaw. |
| doi_str_mv | 10.1177/154405910808700811 |
| format | Article |
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Our results show that cultured rat tooth bud cells, seeded onto biodegradable scaffolds, implanted into the jaws of adult rat hosts and grown for 12 weeks, formed small, organized, bioengineered tooth crowns, containing dentin, enamel, pulp, and periodontal ligament tissues, similar to identical cell-seeded scaffolds implanted and grown in the omentum. Radiographic, histological, and immunohistochemical analyses showed that bioengineered teeth consisted of organized dentin, enamel, and pulp tissues. This study advances practical applications for dental tissue engineering by demonstrating that bioengineered tooth tissues can be regenerated at the site of previously lost teeth, and supports the use of tissue engineering strategies in humans, to regenerate previously lost and/or missing teeth. The results presented in this report support the feasibility of bioengineered replacement tooth formation in the jaw.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910808700811</identifier><identifier>PMID: 18650546</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Absorbable Implants ; Animals ; Biocompatible Materials ; Bone Regeneration ; Calcification, Physiologic - physiology ; Cell Culture Techniques ; Cell Differentiation ; Cell Transplantation - methods ; Dental Enamel Proteins - metabolism ; Dentin - metabolism ; Dentistry ; Mandible - surgery ; Odontogenesis - physiology ; Rats ; Rats, Inbred Lew ; Tissue Engineering - methods ; Tissue Scaffolds ; Tooth - cytology ; Tooth - growth & development ; Tooth - metabolism ; Tooth - transplantation ; Tooth Germ - cytology ; Tooth Germ - growth & development ; Tooth Germ - metabolism ; Tooth Germ - transplantation ; Tooth Socket - surgery</subject><ispartof>Journal of dental research, 2008-08, Vol.87 (8), p.745-750</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry Aug 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-16d502ca215e8ebee470264106e383b8291f176193a5a9a565e97cca9a6145703</citedby><cites>FETCH-LOGICAL-c562t-16d502ca215e8ebee470264106e383b8291f176193a5a9a565e97cca9a6145703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/154405910808700811$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/154405910808700811$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,780,784,885,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18650546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duailibi, S.E.</creatorcontrib><creatorcontrib>Duailibi, M.T.</creatorcontrib><creatorcontrib>Zhang, W.</creatorcontrib><creatorcontrib>Asrican, R.</creatorcontrib><creatorcontrib>Vacanti, J.P.</creatorcontrib><creatorcontrib>Yelick, P.C.</creatorcontrib><title>Bioengineered Dental Tissues Grown in the Rat Jaw</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Our long-term objective is to develop methods to form, in the jaw, bioengineered replacement teeth that exhibit physical properties and functions similar to those of natural teeth. Our results show that cultured rat tooth bud cells, seeded onto biodegradable scaffolds, implanted into the jaws of adult rat hosts and grown for 12 weeks, formed small, organized, bioengineered tooth crowns, containing dentin, enamel, pulp, and periodontal ligament tissues, similar to identical cell-seeded scaffolds implanted and grown in the omentum. Radiographic, histological, and immunohistochemical analyses showed that bioengineered teeth consisted of organized dentin, enamel, and pulp tissues. This study advances practical applications for dental tissue engineering by demonstrating that bioengineered tooth tissues can be regenerated at the site of previously lost teeth, and supports the use of tissue engineering strategies in humans, to regenerate previously lost and/or missing teeth. The results presented in this report support the feasibility of bioengineered replacement tooth formation in the jaw.</description><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Bone Regeneration</subject><subject>Calcification, Physiologic - physiology</subject><subject>Cell Culture Techniques</subject><subject>Cell Differentiation</subject><subject>Cell Transplantation - methods</subject><subject>Dental Enamel Proteins - metabolism</subject><subject>Dentin - metabolism</subject><subject>Dentistry</subject><subject>Mandible - surgery</subject><subject>Odontogenesis - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><subject>Tooth - cytology</subject><subject>Tooth - growth & development</subject><subject>Tooth - metabolism</subject><subject>Tooth - transplantation</subject><subject>Tooth Germ - cytology</subject><subject>Tooth Germ - growth & development</subject><subject>Tooth Germ - metabolism</subject><subject>Tooth Germ - transplantation</subject><subject>Tooth Socket - surgery</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1LAzEQhoMoWqt_wIMsHrytzmSTbPYiaP1GEETPId1Oa2S7W5OtxX9vlhY_wVPC5J0n7zvD2B7CEWKeH6MUAmSBoEHnABpxjfW6YtpV11kPgPMUMiG32HYILwBYcJ1tsi3USoIUqsfwzDVUT1xN5GmUnFPd2ip5dCHMKSRXvlnUiauT9pmSB9smt3axwzbGtgq0uzr77Ony4nFwnd7dX90MTu_SUirepqhGEnhpOUrSNCQSOXAlEBRlOhtqXuAYc4VFZqUtrFSSirws41WhkDlkfXay5M7mwymNyujM28rMvJta_24a68zPl9o9m0nzZjLgQuoOcLgC-OY1pmnN1IWSqsrW1MyDUUWcTLQRhQe_hC_N3NcxnOFQCMUROhpfikrfhOBp_OkEwXTrMH_XEZv2v2f4alnNPwqOl4JgJ_T17T_IDwogkBo</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Duailibi, S.E.</creator><creator>Duailibi, M.T.</creator><creator>Zhang, W.</creator><creator>Asrican, R.</creator><creator>Vacanti, J.P.</creator><creator>Yelick, P.C.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200808</creationdate><title>Bioengineered Dental Tissues Grown in the Rat Jaw</title><author>Duailibi, S.E. ; Duailibi, M.T. ; Zhang, W. ; Asrican, R. ; Vacanti, J.P. ; Yelick, P.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-16d502ca215e8ebee470264106e383b8291f176193a5a9a565e97cca9a6145703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Absorbable Implants</topic><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Bone Regeneration</topic><topic>Calcification, Physiologic - physiology</topic><topic>Cell Culture Techniques</topic><topic>Cell Differentiation</topic><topic>Cell Transplantation - methods</topic><topic>Dental Enamel Proteins - metabolism</topic><topic>Dentin - metabolism</topic><topic>Dentistry</topic><topic>Mandible - surgery</topic><topic>Odontogenesis - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds</topic><topic>Tooth - cytology</topic><topic>Tooth - growth & development</topic><topic>Tooth - metabolism</topic><topic>Tooth - transplantation</topic><topic>Tooth Germ - cytology</topic><topic>Tooth Germ - growth & development</topic><topic>Tooth Germ - metabolism</topic><topic>Tooth Germ - transplantation</topic><topic>Tooth Socket - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duailibi, S.E.</creatorcontrib><creatorcontrib>Duailibi, M.T.</creatorcontrib><creatorcontrib>Zhang, W.</creatorcontrib><creatorcontrib>Asrican, R.</creatorcontrib><creatorcontrib>Vacanti, J.P.</creatorcontrib><creatorcontrib>Yelick, P.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Career and Technical Education</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duailibi, S.E.</au><au>Duailibi, M.T.</au><au>Zhang, W.</au><au>Asrican, R.</au><au>Vacanti, J.P.</au><au>Yelick, P.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioengineered Dental Tissues Grown in the Rat Jaw</atitle><jtitle>Journal of dental research</jtitle><addtitle>J Dent Res</addtitle><date>2008-08</date><risdate>2008</risdate><volume>87</volume><issue>8</issue><spage>745</spage><epage>750</epage><pages>745-750</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><coden>JDREAF</coden><abstract>Our long-term objective is to develop methods to form, in the jaw, bioengineered replacement teeth that exhibit physical properties and functions similar to those of natural teeth. 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The results presented in this report support the feasibility of bioengineered replacement tooth formation in the jaw.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>18650546</pmid><doi>10.1177/154405910808700811</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of dental research, 2008-08, Vol.87 (8), p.745-750 |
| issn | 0022-0345 1544-0591 |
| language | eng |
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| source | MEDLINE; Sage Journals |
| subjects | Absorbable Implants Animals Biocompatible Materials Bone Regeneration Calcification, Physiologic - physiology Cell Culture Techniques Cell Differentiation Cell Transplantation - methods Dental Enamel Proteins - metabolism Dentin - metabolism Dentistry Mandible - surgery Odontogenesis - physiology Rats Rats, Inbred Lew Tissue Engineering - methods Tissue Scaffolds Tooth - cytology Tooth - growth & development Tooth - metabolism Tooth - transplantation Tooth Germ - cytology Tooth Germ - growth & development Tooth Germ - metabolism Tooth Germ - transplantation Tooth Socket - surgery |
| title | Bioengineered Dental Tissues Grown in the Rat Jaw |
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