Tumor-secreted PGE2 Inhibits CCL5 Production in Activated Macrophages through cAMP/PKA Signaling Pathway

One of the major characteristics of tumors is their ability to evade immunosurveillance through altering the properties and functions of host stromal and/or immune cells. CCL5 has been shown to play important roles in T cell proliferation, IFN-γ, and IL-2 production, which promotes the differentiati...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (3), p.2111-2120
Hauptverfasser:	Qian, Xuesong, Zhang, Jidong, Liu, Jianguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bacterial Infections - metabolism Breast Cancer Cell Line Chemokine CCL5 - biosynthesis Chemokines Colforsin - pharmacology Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Dinoprostone - antagonists & inhibitors Dinoprostone - metabolism Innate Immunity Interferon-gamma - metabolism Interleukin-2 - metabolism Isoquinolines - pharmacology Lipopolysaccharide (LPS) Lipopolysaccharides - pharmacology Macrophage Activation Macrophages - metabolism Male Mice Mice, Inbred BALB C Neoplasms, Experimental - metabolism Nitrobenzenes - pharmacology Prostaglandin Antagonists - pharmacology Protein Kinase Inhibitors - pharmacology Shock, Septic - chemically induced Shock, Septic - metabolism Signal Transduction Sulfonamides - pharmacology Tumor Escape - drug effects Xanthones - pharmacology
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