Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes

Resting intracellular Ca(2+) can be raised, in neonatal rat cardiac myocytes, by exposure to very low concentration of thapsigargin (TG). Such a Ca(2+) rise yields calcineurin (CN) activation demonstrated by increased expression of transfected luciferase cDNA under control of nuclear factor of activ...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2011-01, Vol.300 (1), p.H173-H180
Hauptverfasser:	Prasad, Anand Mohan, Inesi, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Blotting, Western Calcineurin - genetics Calcineurin - metabolism Calcium - metabolism Cells, Cultured Fluorescent Antibody Technique Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Signaling and Stress Response Thapsigargin - pharmacology Up-Regulation
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