The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects

Although Δ9-tetrahydrocannabinol (THC) and other mixed CB1/CB2 receptor agonists are well established to elicit antinociceptive effects, their psychomimetic actions and potential for abuse have dampened enthusiasm for their therapeutic development. Conversely, CB2 receptor-selective agonists have be...

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Veröffentlicht in:	Neuropharmacology 2011-02, Vol.60 (2-3), p.244-251
Hauptverfasser:	Kinsey, Steven G., Mahadevan, Anu, Zhao, Bingjun, Sun, Hang, Naidu, Pattipati S., Razdan, Raj K., Selley, Dana E., Imad Damaj, M., Lichtman, Aron H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cannabinoids - pharmacology Cannabinoids - therapeutic use CB1 CB2 Cyclohexanols - pharmacology Cyclohexanols - therapeutic use Dose-Response Relationship, Drug Dronabinol - analogs & derivatives Dronabinol - chemistry Dronabinol - pharmacology Dronabinol - therapeutic use Endogenous cannabinoid agonist Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - psychology Lipopolysaccharide induced edema Male Mice Neuropathic pain Pain - drug therapy Pain - physiopathology Pain Measurement Piperidines - pharmacology Pyrazoles - pharmacology Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - physiology
Online-Zugang:	Volltext
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